Sarcopenia Sarcopenia
Conditions
Interventions
Participants will undertake a 12-week Progressive Resistance and Weight-Bearing Exercise (PRWBE) program supported by the SarcMonitor and Care system. Exercise intensity will be individualized and pro
PRWBE with SarcMonitor and Care System,Conventional PRWBE,control
Sponsors
Research Grant of Burapha University through National Research Council of Thailand
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Male or female participants aged 50 years and older. 2.Diagnosed with low muscle mass according to the Asian Working Group for Sarcopenia (AWGS) criteria. 3.Able to walk independently or with the use of a walking aid. 4.Able to perform movements or lower-limb exercise in a standing position. 5.Not engaged in regular resistance or aerobic exercise (2 days per week)within the past 6 months prior to study participation. 6.Have never been diagnosed with cardiovascular disease, neurological disease, or chronic respiratory diseases.
Exclusion criteria
Exclusion criteria: 1.Unable to communicate during physical assessment. 2.Having visual impairment that cannot be corrected with eyeglasses, such as all types of cataracts or diabetic retinopathy. 3.Currently having uncontrolled hypertension. 4.History of allergy to electromyography (EMG) surface electrodes. 5.High risk for exercise participation, defined as: 5.1) Classified as high risk according to the pre-exercise risk stratification criteria of the American College of Sports Medicine (ACSM), or 5.2) Having moderate cardiovascular risk (score > 2) based on the Cardiovascular Disease (CVD) Risk Factor Assessment, and the physician determines that the participant is not suitable for testing in this study. 6.Unable to adhere to a 12-week exercise program (exercise group only). 7.Currently diagnosed with inflammatory joint disease. 8.Received corticosteroid injection in the quadriceps muscle or patellar tendon within 1 year prior to study participation. 9.Long-term use of corticosteroids for more than 1 month. 10.Currently using medications or dietary supplements that may affect muscle adaptations to training. 11.Having abnormalities or disabilities of the lower extremities, or joint contractures of the lower limbs that limit movement or prevent participation in the prescribed resistance exercise program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skeletal muscle mass baseline 8 weeks and 12 weeks Measured by Dual Energy X ray Absorptiometry DEXA and InBody bioelectrical impedance analysis,Muscle strength baseline 8 weeks and 12 weeks Measured by handgrip dynamometer knee and ankle strength using BIODEX system and heel raise test,Physical performance baseline 8 weeks and 12 weeks Measured by 10 meter walk test Timed Up and Go test and Five Times Sit to Stand test | — |
Secondary
| Measure | Time frame |
|---|---|
| Body composition Baseline, 8 weeks, 12 weeks InBody bioelectrical impedance analysis ,Bone mineral density Baseline, 8 weeks, 12 weeks DEXA at femur and lumbar spine,Electromyography activity Baseline, 8 weeks, 12 weeks Surface EMG (Noraxon TeleMyo DTS) during maximal voluntary contraction,Muscle morphology Baseline, 8 weeks, 12 weeks Ultrasound imaging (B-mode, Mindray M5 series),Physical activity level Baseline, 8 weeks, 12 weeks Global Physical Activity Questionnaire (GPAQ),Quality of life Baseline, 8 weeks, 12 weeks EQ-5D-5L and sarcopenia-specific quality of life questionnaire,Depression Baseline, 8 weeks, 12 weeks Thai Geriatric Depression Scale (TGDS, 30 items),Fall risk Baseline, 8 weeks, 12 weeks Thai Falls Risk Assessment Test (Thai-FRAT),Nutritional status Baseline, 8 weeks, 12 weeks Mini Nutritional Assessment (MNA),Adverse events Continuous throughout 12-week intervention Weekly monitoring and participant self-report (e.g., DOMS, fatigue, injury),Participant satisfaction Week 12 only Structured satisfaction questionnaire | — |
Countries
Thailand
Contacts
Public ContactSIRIRAT KIATKULANUSORN
Burapha University, Thailand
Outcome results
None listed