Cirrhosis Minimal Hepatic Encephalopathy Cirrhosis Minimal Hepatic Encephalopathy Psychometric Hepatic Encephalopathy Scpre Whey protein
Conditions
Interventions
Fresubin whey protein 22 gram per day for 12 weeks,Maltodextrin 22 gram per day for 12 weeks
Active Comparator Dietary Supplement,Placebo Comparator Dietary Supplement
Whey protein,Maltodextrin
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75 years with a diagnosis of liver cirrhosis 2. Presence of MHE, defined by PHES score less than or equal -5
Exclusion criteria
Exclusion criteria: 1.History of acute decompensation of cirrhosis within the past 3 months 2. Active alcohol consumption within the past 3 months 3. Active use of psychotropic drugs (antipsychotic, anxiolytic, or antidepressant) 4. History of oral nutritional supplement use within 2 weeks 5. MELD score more than 20 6. Known allergy to whey protein 7. Estimated glomerular filtration rate < 60 mL/min/1.73 m2 8. Presence of active malignancy 9. Pregnant or currently breastfeeding 10. Severe cardiopulmonary or neuropsychological diseases 11. Patients who cannot follow commands or have functional disabilities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PHES score 12 weeks PHES score | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional status 12 weeks ASM, Handgrip strength, Physcial performance,CTP, MELD score 12 weeks CTP/MELD score,Laboratory marker 12 weeks Pre-albumin, ammonia, IL6, TNF alpha, LPS, LBP,QoL 12 weeks SF 36 | — |
Countries
Thailand
Contacts
Public ContactChuti Burana
King Chulalongkorn Memorial Hospital
Outcome results
None listed