Efficacy of Antiseizure Medications in Preventing Epilepsy After Ischemic Stroke: A Randomized Controlled Study in At-Risk Patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260601016

Enrollment

248

Registered

2026-06-01

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke epilepsy a. Acute ischemic stroke b. Post stroke epilepsy or late post stroke seizure c. Early post stoke seizure d. TOAST classification e. Large vessel atherosclerosis f. Cardioembolic stroke g. NIHSS score h. Modified ranking scale

Interventions

Lacosamide two oral doses of 50 mg each for first 2 weeks then titrate to 200 mg daily, divided into two oral doses of 100 each This regimen will be maintained for a total of three months.,identical i

Experimental Drug,Placebo Comparator No treatment

Lacosamide,Placebo

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1 Age > 18 years or more 2 Newly diagnosed with acute ischemic stroke at hospitals within the network confirm by brain imaging including computer tomography (CT) scan or magnetic resonance imaging (MRI) 3 SeLECT score > 4 or more, indicating moderate to very high risk for post-stroke epilepsy 4 Patients and/or their caregivers provide informed consent and are willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1 Unstable medical disease included any degree atrioventricular block 2 Intracranial tumors 3 Progressive neurodegenerative disorders 4 Encephalitis or meningitis within 3 years 5 ASM use within 3 months 6 Severe chronic liver disease classified as Child-Pugh class C 7 Severe renal dysfunction (CrCl <30 mL/min) 8 Major psychiatric disorders 9 Severe intellectual disability 10 Pregnant or lactation 11 Known history of epilepsy 12 Status epilepticus

Design outcomes

Primary

Measure	Time frame
Incidence of post stroke-epilepsy 18 months 1 single seizure event	—

Secondary

Measure	Time frame
Functional outcome 3, 6, 9, 12, 15, 18 months modified ranking scale,Complication 1 and 3 months Clinical questionare,Mortality rate 18 months death event	—

Countries

Thailand

Contacts

Public ContactSomjet Tosamran

King Chulalongkorn Memorial Hospital

toon_tae_zaa@docchula.com022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026