HIV weight gain TAF body composition metabolic
Conditions
Interventions
TDF 300 MG + 3TC 300 MG + DTG 50 MG 1 tablets oral once daily,FTC 200 MG + TAF 25 MG + DTG 50 MG 1 tablets oral once daily
Active Comparator Drug,Active Comparator Drug
TDF,TAF
Sponsors
The Fogarty International Center at the U.S. National Institutes of Health (NIH)
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. PLWH aged between 20-80 years 2. Received TDF/3TC/DTG 3. CrCL more than 50 ml/min 4. No history of bone fracture or osteoporosis or osteopenia 5. No significant change in body weight (weight gain or lose less than 5% in 1 year apart) 6. Able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Currently on latent tuberculosis treatment 2. Pregnancy 3. Inability or unwillingness to adhere to scheduled follow-up visits. 4. Planned relocation outside the study area during the intervention period 5. Active substance abuse or undergoing treatment for alcohol addiction 6. Previous bariatric or significant gastrointestinal surgeries aimed at weight reduction 7. Use of pharmacologic weight-loss agents (oral or injectable) within 3 months prior to enrollment 8. Receiving immunosuppressive therapy including systemic corticosteroids 9. Current hormonal replacement therapy 10. Presence of any medical or psychological condition judged by investigators to interfere significantly with study participation or compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| body fat mass at the beginning of study and at 6 months kg | — |
Secondary
| Measure | Time frame |
|---|---|
| Body weight at the beginning of study and at 6 months kg,waist circumference at the beginning of study and at 6 months cm.,LDL at the beginning of study and at 6 months mg/dl,skeleton muscle mass at the beginning of study and at 6 months kg,FBS at the beginning of study and at 6 months mg/dl,triglyceride at the beginning of study and at 6 months mg/dl,HbA1C at the beginning of study and at 6 months % | — |
Countries
Thailand
Contacts
Public ContactKawisara Krasaewes
Chiang mai university
Outcome results
None listed