Mild-to-moderate acne vulgaris patients aged 18-40 years acne, skin tolerability, EGCG, L-carnitine, moisturizer, adapalene
Conditions
Interventions
Active group:
Moisturizer containing 5% epigallocatechin gallate (EGCG) and 2% L-carnitine (LC) with 5% dimethicone and glycerin with topical 0.1% adapalene,Control group:
Moisturizer containing 5% d
Experimental Drug,Active Comparator Drug
Moisturizer containing 5% epigallocatechin gallate (EGCG) and 2% L-carnitine (LC) with 5% dimethicone and glycerin with topical 0.1% adapalene,Moisturizer containing 5% dimethicone and glycerin with
Sponsors
Prof. Montree Udompataikul
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Participants aged 18 to 40 years. 2. Participants diagnosed with mild to moderate acne vulgaris. 3. Participants with Investigator's Global Assessment (IGA) score of 2 or 3. 4. Participants willing to comply with the study protocol and attend all scheduled visits. 5. Participants who provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. Participants with hypersensitivity to any study product. 2. Participants who received oral antibiotics for acne within 4 weeks before enrollment. 3. Participants who received isotretinoin within 12 weeks before enrollment. 4. Participants who received oral contraceptives within 12 weeks before enrollment. 5. Participants who used other topical anti-acne agents within 4 weeks before enrollment. 6. Participants with disorders associated with acne, including polycystic ovary syndrome or hyperandrogenism. 7. Participants who received energy-based device treatment affecting sebaceous activity, such as monopolar radiofrequency or fractional laser, within 6 months before enrollment. 8. Participants with active facial infection. 9. Participants with other facial dermatoses, such as vitiligo or psoriasis. 10. Participants who were pregnant or lactating. 11. Participants who were unable to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Worst Score (GWS) 8 weeks the arithmetic mean of the maximum (worst) severity across visits for each of the five signs and symptoms (erythema, dryness, burning, pruritus, scaling) | — |
Secondary
| Measure | Time frame |
|---|---|
| Acne lesion counts 8 weeks acne lesion counts with Leeds revised acne system,Facial sebum 8 weeks Sebumeter,Transepidermal water loss (TEWL) 8 weeks Tewameter,Skin hydration 8 weeks Corneometer | — |
Countries
Thailand
Contacts
Public ContactMontree Udompataikul
Department of Dermatology, Faculty of Medicine, Srinakharinwirot University
Outcome results
None listed