Mild to moderate dry eyes patients dry eye disease, Ocular Surface Disease Index, ocular surface staining, tear break up time, probiotic
Conditions
Interventions
Oral probiotic containing 3 specific species (Lactobacillus paracasei MSMC 39-1, Lactobacillus reuteri TF-314, Bifidobacterium animalis TA-1) in capsule form is taken 1 capsule daily in the morning fo
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Oral probiotic,Maltodextrin
Sponsors
Faculty of medicine, Srinakharinwirot university
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: A patient with T-OSDI score of more than 13 points with at least one of the following sign 1. ocular surface staining defines as cornea staining more than 5 spots OR conjunctival staining more than 9 spots OR eyelid margin staining length more than 2 mm and width more than 25% 2. Tear break up time less than 10 seconds
Exclusion criteria
Exclusion criteria: 1. pregnant or lactating 2. underlying ocular (lacrimal or corneal disease) or systemic disease (autoimmune or neurologic disease) 3. previous ocular surgery or refractive surgery within 1 year 4. contact lens use (within 1 yr) 5. current topical medication; steroid , secretagogues, cyclosporine 6. current systemic medication: steroid, vitamin A derivative, hormone replacement therapy, oral contraceptive pill,beta-blocker, psychiatric pill, antihistamine, sedative/sleeping pill, regular analgesic 7. previously or currently taking probiotic 8. allergic to probiotic 9. contraindicated for probiotic: immunocompromised, Hx of chemotherapy, structural heart disease 10. allergy to maltodextrin 11. history of antibiotic use (within 60 days)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non- invasive tear break up time at 1 month after the end of the intervention Keratograph 5M | — |
Secondary
| Measure | Time frame |
|---|---|
| Ocular surface staining At 1 month after the end of the intervention Fluorescein staining,Lipid layer thickness/quality at 1 month after the end of the intervention Keratograph 5M,Conjunctival redness at 1 month after the end of the intervention Keratograph 5M ,Tear osmolarity at 1 month after the end of the intervention TearLab osmolarity test card ,Dry eyes symptoms at 1 month after the end of the intervention T-OSDI questionaire | — |
Countries
Thailand
Contacts
Public ContactSumalee Boonyaleephan
Srinakharinwirot university
Outcome results
None listed