Systemic lupus erythematosus Infection Lupus erythematosus, systemic C-reactive protein Prospective studies
Conditions
Interventions
Patient with inactive SLE, defined by clinical Systemic Lupus Erythematosus Disease Activity Index-2000 (cSLEDAI-2K) of lower than 4, without infection,Patient with inactive SLE, defined by clinical S
Inactive SLE without infection,Inactive SLE with infection,Active SLE without infection,Active SLE with infection
Sponsors
Siriraj Hospital, Mahidol University, Bangkok, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Systemic lupus erythematosus patient diagnosed by 2019 ACR/EULAR classification criteria, at least 18 years of age at enrollment, that visited rheumatology clinic or admitted into Siriraj Hospital
Exclusion criteria
Exclusion criteria: 1. Overlapping syndrome 2. Active cancer 3. Pregnancy 4. Recent trauma or surgery within 2 weeks 5. Recent myocardial infection or stroke within 2 weeks 6. Antibiotic treatment within 72 hours from CRP collection 7. Patient with history of suspected infection with onset more than 14 days before OPD visit 8. Cirrhosis 9. Combined oral contraceptive pills usage 10. Receiving IL-6 antagonist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRP Cut-point for infection The end of study ROC curve | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference of CRP value in IPD and OPD patient with infection At the end of study Comparison,Predictor of infection in SLE patient At the end study Odd ratios,Comparison of CRP in patient with and without infection or flare At the end of study Comparison | — |
Countries
Thailand
Contacts
Public ContactSirawit Chaiyamahapurk
Division of Rheumatology, Department of Internal Medicine, Siriraj Hospital, Thailand
Outcome results
None listed