Post-washing skin hydration and epidermal barrier function in healthy adults. Moisturizer, Skin hydration, Stratum corneum hydration, Transepidermal water loss, Washing
Conditions
Interventions
Control condition. After the second water-only wash, no moisturizer was applied to the assigned anatomical test site. ,The study moisturizer was Base Cream from Rajaprajasamasai Institute, Department
No moisturizer control,Moisturizer application at 2 minutes after washing,Moisturizer application at 5 minutes after washing,Moisturizer application at 10 minutes after washing,Moisturizer application
Sponsors
Mae Fah Luang University, Thailand
Eligibility
Sex/Gender
All
Age
19 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Healthy adults aged 21 to 65 years 2. Able to understand the study procedures 3. Willing to provide written informed consent before enrollment.
Exclusion criteria
Exclusion criteria: 1. Current or previous chronic inflammatory dermatoses involving the intended test areas, such as atopic dermatitis, psoriasis, or allergic contact dermatitis 2. Active inflammation, or local infection at the test sites 3. Use of topical or systemic agents that could affect skin hydration or barrier-related outcomes, such as corticosteroids, retinoids, or immunosuppressants, within 2 weeks before participation 4. Pregnancy or breastfeeding 5. Medical conditions that could impair skin barrier function, such as uncontrolled diabetes mellitus, chronic kidney failure, or immune/autoimmune disorders 6. Known allergy or irritation to the study moisturizer or its ingredients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stratum corneum hydration and Transepidermal water loss Baseline, 30 minutes, 60 minutes, and 90 minutes after moisturizer application Corneometer and Tewameter | — |
Secondary
| Measure | Time frame |
|---|---|
| NA NA NA | — |
Countries
Thailand
Contacts
Public ContactBhakinai Temnithikul
School of Anti-aging and Regenerative Medicine, Mae Fah Luang University
Outcome results
None listed