Persistent unexplained dizziness in adults aged 45 to 60 years lasting at least 4 weeks, without identifiable vestibular or central neurological cause requiring specific treatment. dizziness vertigo chronic dizziness unexplained dizziness Yahom Thepajit Thai herbal medicine complementary medicine randomized controlled trial placebo controlled DHI VAS vestibular symptoms
Conditions
Interventions
Yahom Thepajit 1000 mg per day for 1 month,Matching placebo
Active Comparator Drug,Placebo Comparator Drug
Yahom Thepajit ,Placebo
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age between 45 and 60 years. 2. Presenting with unspecified dizziness lasting at least 4 weeks. 3. Completed standard ENT and vestibular assessment without abnormalities in: * basic neurotologic examination * orthostatic hypotension assessment * nystagmus evaluation * Dix-Hallpike maneuver 4. No evidence of acute life-threatening or central neurologic cause requiring immediate specific therapy. 5. Able to understand and complete the Thai version of the DHI questionnaire.
Exclusion criteria
Exclusion criteria: 1. Patient with clearly defined vestibular disorder requiring specific treatment such as known active Menieres disease acute vestibular neuritis acute labyrinthitis. 2. Patient with renal or hepatic disease such as acute renal injury chronic kidney disease GFR less than 90 cirrhosis hepatocellular carcinoma elevated liver enzyme more than twofold of normal level. 3. Uncontrolled hypertension or clinically significant arrhythmia. 4. Known allergy or intolerance to any ingredient of Yahom Thepajit. 5. Current pregnancy or breastfeeding. 6. Severe psychiatric disorders or cognitive impairment interfering with consent or questionnaire completion. 7. Use of medications with potential herb drug interactions that cannot be safely discontinued or stabilized such as Warfarin Digoxin antiepileptic anticoagulant antiplatelet.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Dizziness Handicap Inventory score 1 month After intervention Dizziness Handicap Inventory score measured using Thai validated questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Dizziness Handicap Inventory score 2 week after intervention Dizziness Handicap Inventory score measured using Thai validated questionnaire,Change in Visual Analog Scale score 2 week, 1 month Change in Visual Analog Scale score,Responder rate based on Dizziness Handicap Inventory improvement 1 month Responder rate defined as at least 18 point improvement in Dizziness ,Adverse events 2 week, 1 month patient report and clinical assessment,Change in heart rate and blood pressure 2 week, 1 month Heart rate and blood pressure measured using standard clinical methods,Correlation between Dizziness Handicap Inventory and Visual Analog Scale 1 month statistical methods | — |
Countries
Thailand
Contacts
Public ContactKanokrat Suvarnsit
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed