A comparative study of the sensitivity and specificity of computed tomography of the neck in extended and neutral positions in patients with substernal goiter

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260521003

Enrollment

Registered

2026-05-21

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

substernal goiter computed tomography, neck extension, substernal goiter, surgery, thyroid

Interventions

1. Position the patient in a neutral position, lying flat (supine) with arms at their sides, and support the head with a head ring. 2. Perform a pre-contrast CT scan in the neutral position. 3. Reposi

Experimental Other

CT neck extension

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: - Patients aged between 18 and 70 years. - Patients diagnosed with secondary substernal goiter based on preliminary physical examination (i.e., the lower border of the mass cannot be palpated even with full neck extension) or radiographic findings suspicious of intrathoracic thyroid extension. - Patients who have indications for and intend to undergo thyroid surgery (total thyroidectomy, lobectomy, or subtotal thyroidectomy).

Exclusion criteria

Exclusion criteria: - Patients with contraindications to computed tomography (CT) scan (e.g., history of severe contrast media allergy, pregnancy). - Patients who cannot receive contrast media due to abnormal renal function. - Diabetic patients with Serum Creatinine (Cr) > 2.0 mg/dL or estimated Glomerular Filtration Rate (eGFR) < 30 - Non-diabetic patients with Serum Creatinine (Cr) > 3.0 mg/dL or estimated Glomerular Filtration Rate (eGFR) < 15 - Patients with cervical spine disorders who are unable to undergo neck extension, which could potentially cause injury. - Patients with severe dyspnea caused by upper airway obstruction when in the supine position. - Patients with a history of prior thyroid, neck, or open-chest surgery (sternotomy/thoracotomy).

Design outcomes

Primary

Measure	Time frame
The sensitivity and specificity of computed tomography of the neck in extended and neutral positions in patients with substernal goiter When the CT scan and surgery are performed number of case in each group	—

Secondary

Measure	Time frame
To evaluate the displacement distance of the thyroid gland during neck extension When neck CT scans are performed in both neutral and extension positions millimeter	—

Countries

Thailand

Contacts

Public ContactPranpriya Booranaudom

Department of Otolaryngology, Faculty of Medicine, Khon Kaen University

ent.kku@gmail.com043363565

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026