Intertrochanteric Hip Fracture Tranexamic Acid Fracture Fixation Intramedullary Intertrochanteric Fractures Blood Loss Surgical Hip Fractures Aged Randomized Controlled Trial Postoperative Hemorrhage Drug Delivery Systems Injections Saline Solution Treatment Outcome
Conditions
Interventions
2 grams of Tranexamic acid injected into femur intramedullary canal after proximal reaming.,40 mL of saline injected into femur intramedullary canal after proximal reaming.
Experimental Drug,Placebo Comparator Drug
Tranexamic acid injection,Placebo
Sponsors
Research and International Relations Division, Faculty of Medicine, Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Eligible participants were patients aged 60 years or older with a closed intertrochanteric femoral fracture (AO/OTA 31-A) deemed amenable to closed reduction and fixation with a PFNA. 2. American Society of Anesthesiologists (ASA) physical status of I to III.
Exclusion criteria
Exclusion criteria: 1. Known allergy to tranexamic acid. 2. History of myocardial infarction, cerebrovascular accident, deep vein thrombosis, pulmonary embolism, chronic liver disease, or any metabolic disease that would alter coagulation. 3. High risk of venous thrombo-embolism as estimated by Wells' score. 4. Chronic warfarin use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood loss 48 hours after intervention milliliters | — |
Secondary
| Measure | Time frame |
|---|---|
| Hidden blood loss 48 hours after intervention milliliters ,Allogeneic packed red cell transfusion During admission number of units transfused ,Post-operative haemoglobin and haematocrit 48 hours after intervention g/dL, %,30-day complications 30 days postoperative Events | — |
Countries
Thailand
Contacts
Public ContactWittawat Boonyanuwat
Srinakharinwirot University
Outcome results
None listed