Postoperative pain following hemorrhoidectomy in Grade III and IV hemorrhoids patients hemorrhoidectomy, postoperative pain, diazepam
Conditions
Interventions
diazepam 2 mg and placebo of diazepam 5 mg,diazepam 5 mg and placebo of diazepam 2 mg,placebo of diazepam 2 mg and placebo of diazepam 5 mg
diazepam2,diazepam 5 mg,placebo
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Hemorrhoid grades 3 and 4 2. Undergo Hemorrhoidectomy 3. Age 20-60 years 4. Consent to Participate in Research
Exclusion criteria
Exclusion criteria: 1. Patients who have a history of Inflammatory bowel disease, anal fissure, anal fistula, colorectal malignancy 2. Patients over the age of 50 who have not undergone a colonoscopy before hemorrhoidectomy to rule out colorectal cancer 3. Patients who have a history of hypersensitivity to diazepam, severe respiratory insufficiency, myasthenia gravis, sleep apnea syndrome, closed angle glaucoma, hepatic insufficiency (cirrhosis, chronic active hepatitis, hepatic fibrosis, acute viral hepatitis) 4. Any psychotic disorder 5. Any cognitive impairment or Inability to communicate 6. Refuse to participate 7. Pregnancy and breastfeeding 8. Received lorazepam, midazolam or diazepam with in 2 weeks before operation 9. Received other benzodiazepine drug than in item 8 10. Received Drug that have major/moderate interaction with diazepam as listed acetaminophen/hydrocordone, Pregabalin, Quetiapine, Duloxetine, Esomeprazole, Cetirizine, Oxycordone, Gabapentin, Baclofen, zolpidem, diphenhydramine, cyclobenzaprine, escitalopram, lisinopril, melatonin, fluoxetine, tramadol, alprazolam.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain 7 days Mean Visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score 48 hours Visual analog scale | — |
Countries
Thailand
Contacts
Public ContactPasakorn Jarumaythitanon
Chiang Mai University
Outcome results
None listed