Distal radius fractures Postoperative pain Distal radius fractures Dexamethasone Postoperative pain Volar locking plate Functional recovery Bone plates
Conditions
Interventions
Participants will receive a single intravenous dose of 8 mg dexamethasone during the induction of anesthesia before the surgical incision.,Participants will receive a single intravenous dose of steril
Experimental Drug,Placebo Comparator Other
Intravenous Dexamethasone 8 mg,Placebo (Normal Saline)
Sponsors
Kamphaeng Phet Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged 18 years or older, 2. Diagnosed with distal radius fracture indicated for open reduction and internal fixation (ORIF) with a volar locking plate, 3. American Society of Anesthesiologists (ASA) physical status I, II, or III, 4.Able to communicate, understand the study information, and provide voluntary written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of allergy to dexamethasone or any component of the study drug, 2. Diagnosis of Diabetes Mellitus (Type 1 or 2) or significant preoperative hyperglycemia, 3. History of continuous corticosteroid use or received steroids within 30 days prior to surgery, 4.Active systemic infection or skin infection at the surgical site, 5.Open fracture or associated severe vascular or nerve injury, 6. Immunocompromised state or currently receiving immunosuppressive drugs, 7.Pregnant, planning pregnancy, or breastfeeding, 8.History of chronic alcoholism or substance abuse, 9. Unable to cooperate with post-operative assessment (e.g., dementia, cognitive impairment, or uncontrolled psychiatric disorders).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total opioid consumption Within the first 48 hours post-operation Cumulative dose of all opioids converted to oral | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score At 6, 12, 24, and 48 hours post-operation Numerical Rating Scale (NRS) ranging from 0 (no pain) to 10 (worst pain imaginable),Finger stiffness At 6, 12, and 24 weeks post-operation Tip-to-palm distance measured in centimeters,Wrist range of motion At 6, 12, and 24 weeks post-operation Degrees of flexion, extension, radial deviation, and ulnar deviation measured by goniometer | — |
Countries
Thailand
Contacts
Public ContactIsarapong Duangmee
Kamphaeng Phet Hospital
Outcome results
None listed