Incremental Value of Lipoprotein(a) in Thai CV Risk Score and PREVENT Models for Detecting Subclinical Coronary Atherosclerosis in Thai Adults With Type 2 Diabetes Mellitus

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20260509003

Enrollment

509

Registered

2026-05-09

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus Cardiovascular disease atherosclerotic cardiovascular disease Coronary artery calcium Lipoprotein(a) type 2 diabetes mellitus Cardiovascular disease atherosclerotic cardiovascular disease Coronary artery calcium Lipoprotein(a)

Interventions

Thai CV Risk Score and PREVENT Models for Detecting Subclinical Coronary Atherosclerosis in Thai Adults With Type 2 Diabetes Mellitus

Diagnostic

T2DM patients with Thai CV Risk - PREVENT

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age 40-75 years old 2. All T2DM patients with Thai CV risk score low-to-moderate risk < 20% 3. Has been diagnosed for type 2 diabetes mellitus equal or more than 3 years 4. Ability to provide written informed consent

Exclusion criteria

Exclusion criteria: 1. Established ASCVD 2. History of myocardial infarction 3. History of cerebrovascular disease or peripheral artery disease 4. History of chronic inflammatory disease 5. Familial hypercholesterolemia 6. Claustrophobia 7. Severe renal impairment (eGFR < 30 ml/min/1.73 m2) 8. Pregnancy 9.Contraindication to CT imaging

Design outcomes

Primary

Measure	Time frame
The incremental change in Area Under the Receiver Operating Characteristic curvefor detection of Coronary artery calcium scoring 3 month Agatston units,Lipoprotein(a) 1 hour nmol/L	—

Secondary

Measure	Time frame
Calibration (Slope and Intercept) 3 month score,Brier Score 3 month score,Sensitivity, Specificity 3 month performance,Positive Predictive Value and Negative Predictive Value 3 month times,Net Reclassification Improvement and Integrated Discrimination Improvement 3 month score,Prevalence of CAC more than 100 AU, CAC equal or more than 300 AU, equal or more than 1000 AU across risk categories defined by Thai CV risk score and PREVENT models 3 month Percentage	—

Measure

Time frame

Calibration (Slope and Intercept) 3 month score,Brier Score 3 month score,Sensitivity, Specificity 3 month performance,Positive Predictive Value and Negative Predictive Value 3 month times,Net Reclassification Improvement and Integrated Discrimination Improvement 3 month score,Prevalence of CAC more than 100 AU, CAC equal or more than 300 AU, equal or more than 1000 AU across risk categories defined by Thai CV risk score and PREVENT models 3 month Percentage

—

Countries

Thailand

Contacts

Public ContactSirikorn Kraisomdech

Faculty of Medicine, Chiang Mai University

kung_sirikorn@hotmail.com053936793

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026