Allergic contact dermatitis from lidocaine and prilocaine cream Allergic contact dermatitis, lidocaine and prilocaine cream
Conditions
Interventions
Patients with allergic contact dermatitis due to lidocaine/prilocaine confirmed by patch testing
Prevention
allergic contact dermatitis due to lidocaine/prilocaine
Sponsors
Strategic Wisdom and Research Institute, Srinakhanarinwirot University, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age greater than or equal to 18 years 2.Patients who develop symptoms after application of topical anesthetic cream and are clinically suspected of allergic contact dermatitis from lidocaine/prilocaine cream by a physician 3.Willingness to participate in the study, able to undergo testing and follow-up, and provision of written informed consent
Exclusion criteria
Exclusion criteria: 1. Presence of any contraindication to patch testing, including at least one of the following: 1.1 Severe dermatitis 1.2 Use of immunosuppressive medications such as nonsteroidal anti-inflammatory drugs, corticosteroids, methotrexate, azathioprine, or cyclosporine within 4 weeks prior to enrollment 1.3 Dermatitis on the back or other test sites 1.4 History of ultraviolet therapy or sunburn at the test site within 21 days prior to enrollment 1.5 Use of topical corticosteroids at the test site within 14 days prior to enrollment 2. Pregnancy or breastfeeding 3. History of severe hypersensitivity reaction (anaphylaxis) to lidocaine/prilocaine cream 4. Known glucose-6-phosphate dehydrogenase (G6PD) deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of allergic contact dermatitis and irritant contact dermatitis from lidocaine or prilocaine cream among patients with suspected symptoms 48, 72, 168 hour Patch testing | — |
Secondary
| Measure | Time frame |
|---|---|
| Allergens identified in patients with allergic contact dermatitis from lidocaine or prilocaine cream 48, 72, 168 hour Patch testing,Factors associated with the development of allergic contact dermatitis and irritant contact dermatitis from lidocaine or prilocaine cream at the beginning of study, Day7 Questionnaire | — |
Countries
Thailand
Contacts
Public ContactSalinee Rojhirunsakool
Faculty of Medicine, Srinakharinwirot University
Outcome results
None listed