Acute leukemia Acute leukemia Bleeding Thrombosis
Conditions
Interventions
Patients with newly diagnosed acute leukemia aged more than 15 years who are observed for the occurrence of bleeding and thrombotic events within 30 days after diagnosis. Data are collected from medic
Other
Acute leukemia patients
Sponsors
Mahidol University
Eligibility
Sex/Gender
All
Age
15 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients aged more than 15 years. 2.Patients newly diagnosed with any type of acute leukemia. Retrospective cohort: Patients diagnosed between January 1, 2020 and December 31, 2023. Prospective cohort: Patients diagnosed after study approval until December 31, 2025.
Exclusion criteria
Exclusion criteria: 1.Patients with a prior history of inherited thrombophilia. 2.Patients who were receiving antiplatelet or anticoagulant therapy prior to the diagnosis of acute leukemia. 3.Patients without baseline laboratory results required for calculating the SiAML-bleeding and SiAML-thrombosis scores at the time of diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of the SiAML-Bleeding and SiAML-Thrombosis scores in predicting bleeding and thrombotic events within 30 days after diagnosis Within 30 days after diagnosis sensitivity, specificity, Positive Predictive Value,Negative Predictive Value,Area Under the Curve | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of bleeding and thrombotic events in patients with newly diagnosed acute leukemia Within 30 days after diagnosis The incidence of thrombotic and bleeding events | — |
Countries
Thailand
Contacts
Public ContactNina Marklieng
Siriraj hospital
Outcome results
None listed