Acute peptic ulcer bleeding with suspected Helicobacter pylori infection Peptic ulcer, Gastrointestinal bleeding, H. pylori
Conditions
Interventions
All enrolled participants will undergo H. pylori testing using the following methods: rapid urease test from gastric biopsy specimens
histology with standard staining and immunohistochemistry
stool H. pylori antigen test using a monoclonal antibody-based immunoassay
and serum IgG antibody test using ELISA.
Diagnostic
Peptic ulcer bleeding patients
Sponsors
The Gastroenterological Association of Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 years 2. Admitted as inpatients with symptoms or signs of acute upper gastrointestinal bleeding 3. Underwent upper gastrointestinal endoscopy showing peptic ulcer bleeding from a gastric or duodenal ulcer 4. Able to provide written informed consent personally or through a legally authorized representative.
Exclusion criteria
Exclusion criteria: 1. Bleeding caused by malignancy, tumor, or non-peptic ulcer lesions 2. Prior PPI use within 2 weeks or antibiotic use within 4 weeks before enrollment 3. Previous H. pylori eradication therapy; previous gastric resection surgery 4. Abnormal bleeding risk or clinical contraindication to gastric biopsy 5. Refusal or withdrawal of consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diagnostic accuracy of different Helicobacter pylori detection 1 day rapid urease test, histology with immunohistochemistry, stool antigen test, and serum IgG antibody, using a hierarchic composite reference standard as the reference diagnosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| diagnostic yield of different H. pylori detection methods 1 day evaluate agreement between diagnostic tests; and to identify clinical or treatment-related factors associated with false-negative results | — |
Countries
Thailand
Contacts
Public ContactArunchai Chang
Hatyai Hospital
Outcome results
None listed