Developing a nano emulsion spray product that utilizes Ma Kwaen (Zanthoxylum limonella (Dennst.) Alston extract for the relief of shoulder muscle discomfort due to office syndrome.

Effectiveness of Makhaen Nanoemulsion Spray Combined with Court type Traditional Thai Massage and Herbal Compress for Relief of Shoulder and Neck Muscle Pain in Individuals with Office Syndrome

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260505013

Enrollment

Registered

2026-05-05

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal pain of the shoulder and neck associated with office syndrome in office workers, resulting from prolonged computer use, static posture, and work related physical strain. Office syndrome, nanoemulsion spray, Zanthoxylum limonella (Dennst.) Alston, product development

Interventions

Participants in the control group receive standard treatment for relief of shoulder pain associated with office syndrome. by Court-type Traditional Thai Massage (C-TTM) Herbal compress therapy In addi

Sham Comparator Other,Active Comparator Drug

Court-type Traditional Thai Massage (C-TTM) Herbal compress therapy,Court-type Traditional Thai Massage (C-TTM) Herbal compress therapy +Makhaen nanoemulsion spray

Eligibility

Sex/Gender

All

Age

25 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Adults of any sex aged 25 to 60 years. 2.Individuals with shoulder pain and clinically diagnosed upper back muscle pain related to office syndrome by a Thai traditional medicine practitioner, with a pain intensity score of four or higher. 3.Individuals in generally good health without underlying diseases that may affect the use of Makhaen extract. 4.Individuals not currently using medications or herbal products with muscle relaxant or anti inflammatory effects. 5.Individuals who voluntarily agree to participate in the study and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1.Individuals with a history of allergy or hypersensitivity to herbal plant extracts, particularly Makhaen, or to any components of the nanoemulsion spray formulation. 2.Individuals with underlying diseases that may affect treatment response, such as chronic skin diseases or severe musculoskeletal disorders. 3.Individuals currently using analgesic medications, muscle relaxants, or other herbal products that may interfere with the evaluation of study outcomes. 4.Individuals who have used nonsteroidal anti inflammatory drugs or steroid medications, either topical or oral, within one week prior to study participation. 5.Pregnant or breastfeeding individuals. Individuals unable to cooperate with the study procedures or unable to participate in outcome assessments according to the scheduled timeline. 6.Individuals who do not agree to provide written informed consent for participation in the study.

Design outcomes

Primary

Measure	Time frame
Shoulder and neck muscle pain intensity at 1 months after end of the intervention Visual Analog Scale (VAS)	—

Secondary

Measure	Time frame
Frequency of improvement in health related quality of life at 1 months after end of the intervention Visual Analog Scale (VAS), Self reported pain duration recorded using a pain diary,overall quality of life (QoL)	—

Countries

Thailand

Contacts

Public ContactKeng Chaichana

school of public health University of Phayao

keng.ch@up.ac.th054466666

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026