Effect of Anti-Inflammatory Solutions on Pain After Root Canal Treatment

EFFECT OF ANTI-INFLAMMATORY IRRIGANTS ON THE POST OPERATIVE PAIN IN ROOT CANAL TREATMENT OF SYMPTOMATIC TEETH: A RANDOMIZED CONTROLLED CLINICAL TRIAL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260505011

Enrollment

110

Registered

2026-05-05

Start date

2024-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic Irreversible Pulpitis Postoperative Pain Root Canal Therapy Therapeutic Irrigation Dexamethasone Sodium Hypochlorite Postoperative Pain Irreversible Pulpitis

Interventions

2 ml of 3% sodium hypochlorite (NaOCl) mixed with 3 ml of sterile saline used as a standard endodontic irrigant, delivered via syringe and activated by a sonic irrigator.,A 10 mg dispersible tablet of

Active Comparator Drug,Experimental Drug,Experimental Drug,Experimental Drug,Experimental Drug

3% Sodium Hypochlorite and Saline,3% Sodium Hypochlorite and 10mg Ketorolac Tromethamine,3% Sodium Hypochlorite and 0.5mg Dexamethasone,10mg Ketorolac Tromethamine and Saline,0.5mg Dexamethasone and S

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients with Symptomatic Irreversible Pulpitis of Molar confirmed by Clinical and Radiographic examination 2. Patients who are willing to participate and sign an informed consent form 3. Patients who are aged between 18 and 65 years and have No Systemic diseases or allergies to the drugs used in the study 4. Patients who have Moderate to Severe pain (4 or above on a Visual Analog Scale) in only One tooth within the 24-hour period before the procedure 5. Patients who have teeth with at least Two-thirds of each root remaining and No Periapical lesions or interradicular radiolucency

Exclusion criteria

Exclusion criteria: 1. Patients younger than 18 or older than 65 years 2. Patients with Systemic diseases 3. Teeth with calcified canals, root resorption, immature/open apex, or previous root canal treatment 4. Teeth with severe damage or mobility 5. Pregnancy or lactation 6. Taking Analgesics or Anti-inflammatory drugs 12 hours before the treatment 7. Exclusion of 3rd molar (Both Maxillary and Mandibular teeth)

Design outcomes

Primary

Measure	Time frame
Postoperative Pain Intensity Preoperative, and at 6, 12, 24, 48, 72 hours, and 7 days postoperatively Visual Analog Scale (VAS)	—

Secondary

Measure	Time frame
Incidence of Adverse Events Up to 7 days postoperatively Clinical Observation	—

Countries

India

Contacts

Public ContactANANDAN KUMAR

Nims University Rajasthan, Jaipur

adityarajkumar2708@gmail.com8999162369

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026