Patient who are willing to remove lower mandibular third molar at both side with moderate to high anxiety according to Corah'
Conditions
Interventions
Dexmedetomidine 1microgram/kg dilute with NSS to total 20 ml., IV drip, slow infusion with infusion pump for 10 minutes,Midazolam 0.1 mg/kg dilute with NSS to total 20 ml., IV drip, slow infusion with
Active Comparator Drug,Active Comparator Drug
Sponsors
Department Of Oral and Maxillofacial surgery, Falculty of dentistry PSU
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1.ASA Classification I II, 2. Thai Patients who are willing to remove impacted third molar on both sides, 3. Moderate to very difficult score 5 to 10 of impacted third molar by Pedersons difficulty index, 4. Moderate to high anxiety score 9 to 14 by Corahs dental anxiety scale, 5. No sign of infection or pericoronitis
Exclusion criteria
Exclusion criteria: 1.Allergy to Dexmedetomidine, Midazolam, Benzodiazepine group, NSAIDs, including COX-2 specific inhibitors, 2.Recent use of benzodiazepine, antidepressants, 3.Clinical history or electrocardiographic evidence of heart block, ischemic heart disease, impaired liver, kidney disease, 4.Respiratory system disorders (asthma, sleep apnea syndrome), 5.Psychiatric disorders such as schizophrenia and depression, 6.Long term analgesic (over 3 months), 7.Breastfeeding or Pregnancy patient, 8.Drug or alcohol addicted, 9.Mental retard
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate Baseline, injection, flap opening, remove bone, separate tooth, suture blood pressure monitor | — |
Secondary
| Measure | Time frame |
|---|---|
| score of anxiety questionnaire before and after surgery Corah's dental anxiety scale,Post-operative pain 1,3,6 hours after surgery VAS score,Time starts rescue drug The pain is unbearable, patient need to take medication subjective pain,Amnesia After surgery when fully awake Able to remember numbers (3 numbers),Nausea and vomitting After surgery Subjective perception,Patient and surgeon satisfaction After surgery (when patient fully awake) Subjective perception | — |
Countries
Thailand
Contacts
Public ContactSurapong Vongvatcharanon
Faculty of Dentistry, Prince of Songkla University
Outcome results
None listed