Post-acne erythema Acne vulgaris Post-inflammatory erythema
Conditions
Interventions
Sea Holly is a Thai herbal medicine from the Acanthaceae family, normally found in the northern part of Thailand. Sea holly extract can inhibit inflammatory cytokines such as interleukin families and
Active Comparator Other,Placebo Comparator Other
Sea Holly Extract gel,Placebo gel
Sponsors
National research council of Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 50 years Male or female sex Post-acne erythema in both cheeks Severity grading of post-acne erythema using Clinician Erythema Assessment Scale (CEA) criteria grade 2 or higher
Exclusion criteria
Exclusion criteria: 1) Known Allergy to sea holly or gel base 2) Currently use of topical retinoid (tretinoin, adapalene, tazarotene) within 12 weeks or systemic retinoid within 6 months 3) facial chemical peeling within 24 weeks 4) Laser treatment within 24 weeks 5) Dermal filler injection, growth factor or PRP (platelet-rich plasma) within 24 weeks 6) Active skin inflammation, infection during screening visit 7) Pregnancy or lactation (female)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigator Global improvement scale 5 ordinal scale between 0-4 | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effect 4 Ordinal scale from 0-4,Time to acne redness recovery period 5 Days,Clinician erythema assessment scale 5 Ordinal scale 0-3,Erythema index by mexameter measurement 5 numeric score,Melanin index by mexameter measurement 5 numeric scale,Patient satisfaction score 1 Likert scale 5 scores | — |
Countries
Thailand
Contacts
Public ContactAssoc. Prof. Dr. Mayuree Kanlayavattanakul
School of Cosmetic Science, Mae Fah Luang University
Outcome results
None listed