The primary outcome measure was the improvement or prevention of postoperative shivering following administration of the study drug. The secondary outcome measure included the frequency of adverse effects associated with each medication. TURP, Pethidine, Tramadol
Conditions
Interventions
To compare improvement in shivering, and frequency of adverse effects in geriatric patients undergoing trans-urethral resection of prostate (TURP).: A total of 860 patients were divided into Group-A t
Experimental Drug
Tramadol and Pethidine arms
Sponsors
None listed
Eligibility
Sex/Gender
Male
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Male patients aged 65 years (geriatric), scheduled for elective trans-urethral resection of the prostate (TURP) under spinal anesthesia, 2. Patients were hemodynamically stable at the time of treatment 3. Patients provided written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with pre-existing fever 2. Patients with baseline hypothermia before spinal anesthesia 3. Patients with active infection/sepsis 4. Patients with known hypersensitivity to tramadol or pethidine/meperidine 5. Patients with chronic opioid use or opioid dependence 6. Patients with a history of seizure disorder 7. Patients with severe hepatic or renal impairment (risk of altered drug metabolism/clearance) 8. Patients with significant respiratory compromise or on room air 9. Patients with clinically significant cardiac instability (ongoing ischemia, uncontrolled arrhythmias, or decompensated heart failure) 10. Patients with cognitive impairment precluding valid consent/assessment 11. Patients using other anti-shivering drugs intra- or post-operatively 12. Patients who were converted to general anesthesia 13. Patients with major intra-operative complications, or refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| consistent with contemporary anesthesia literature 3 hours Crossley and Mahajan shivering scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Shivering 3 hours Crossley and Mahajan shivering scale | — |
Countries
Pakistan
Contacts
Public ContactOsamah Ahmed
NUMS
Outcome results
None listed