Development and Evaluation of a Multicomponent Program to Prevent Frailty for Prefrail Elderly People at Sakon Nakhon Province

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260421006

Enrollment

Registered

2026-04-21

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frailty in older adults Frailty prevention Pre-frail Multicomponent program

Interventions

Integrated Multi-component Exercise and Nutrition Program: 12-week multicomponent intervention consisting of multimodal exercise performed three times per week and nutritional education delivered ove

Experimental Behavioral,Active Comparator Other

Multi-component Program Group,Control group

Eligibility

Sex/Gender

All

Age

60 Years to 74 Years

Inclusion criteria

Inclusion criteria: Phase I 1. Age Range: 60-74 years old. 2. Able to communicate and understand Thai and local dialects. 3. Residency: Must live in Mueang District, Sakon Nakhon Province. 4. Voluntarily agrees to join the study. Phase II 1. Pre-frail or mildly frail status, defined by an Edmonton Frail Scale (EFS) score of 6-9. 2. Functionally independent, with normal ability to perform activities of daily living. 3. Voluntarily agrees to join the study and provide written informed consent.

Exclusion criteria

Exclusion criteria: Phase I 1. Individuals with disabilities or functional impairments. 2. Diagnosed with end-stage renal disease, hepatitis, liver cirrhosis, autoimmune diseases, or cancer. 3. Acute illness (e.g., complicated cardiovascular conditions). Phase II 1. Cognitive impairment, defined as a Montreal Cognitive Assessment-Basic (MoCA-B) score <24. 2. Medical conditions limiting participation in exercise, such as complicated diabetes, acute ischemic heart disease, heart failure, severe hypertension, or severe knee osteoarthritis.

Design outcomes

Primary

Measure	Time frame
frailty score Baseline, 12 weeks, 24 weeks The Edmonton Frail Scale (EFS) questionnaire score	—

Secondary

Measure	Time frame
Physical performance Baseline, 12 weeks, 24 weeks Short Physical Performance Battery (SPPB) score: The assessment includes three components: standing balance, gait speed (4-meter walk), and repetitive chair stand test. ,Grip strength Baseline, 12 weeks, 24 weeks Hand-grip dynamometer (kg),Muscle mass Baseline, 12 weeks, 24 weeks Bioelectrical Impedance Analysis (BIA): recorded in Skeletal Muscle Index (SMI, kg/m2) ,Fat mass / Body composition Baseline, 12 weeks, 24 weeks Bioelectrical Impedance Analysis (BIA): recorded as body fat percentage (%),Nutritional status Baseline, 12 weeks, 24 weeks Mini Nutritional Assessment Short-Form (MNA-SF),cognitive function Baseline, 12 weeks, 24 weeks The Montreal Cognitive Assessment - Basic (MoCA-B) score	—

Measure

Time frame

Physical performance Baseline, 12 weeks, 24 weeks Short Physical Performance Battery (SPPB) score: The assessment includes three components: standing balance, gait speed (4-meter walk), and repetitive chair stand test. ,Grip strength Baseline, 12 weeks, 24 weeks Hand-grip dynamometer (kg),Muscle mass Baseline, 12 weeks, 24 weeks Bioelectrical Impedance Analysis (BIA): recorded in Skeletal Muscle Index (SMI, kg/m2) ,Fat mass / Body composition Baseline, 12 weeks, 24 weeks Bioelectrical Impedance Analysis (BIA): recorded as body fat percentage (%),Nutritional status Baseline, 12 weeks, 24 weeks Mini Nutritional Assessment Short-Form (MNA-SF),cognitive function Baseline, 12 weeks, 24 weeks The Montreal Cognitive Assessment - Basic (MoCA-B) score

—

Countries

Thailand

Contacts

Public ContactBenyapha Sripanya

Kasetsart University

benyapha.phi@ku.th0641536236

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: May 1, 2026