Halitosis Halitosis, Probiotics, Lacticaseibacillus paracasei, Oral health, Older adults, Randomized controlled trial, Crossover study
Conditions
Interventions
Probiotic supplementation containing Lacticaseibacillus paracasei TISTR 2688 will be administered orally once daily, with a matched placebo used in a randomized double blind crossover design including
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Probiotic containing Lacticaseibacillus paracasei TISTR 2688,Placebo
Sponsors
Naresuan University, Thailand
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Aged 60 years and older 2.Clinically diagnosed with halitosis 3.Willing to participate and provide written informed consent 4.Able to comply with study procedures and follow up visits 5.Generally healthy or with stable systemic conditions
Exclusion criteria
Exclusion criteria: 1.Use of antibiotics, probiotics, or antimicrobial mouthwash within the past 4 weeks 2.Presence of severe periodontal disease requiring immediate treatment 3.History of systemic diseases that may affect oral malodor such as uncontrolled diabetes or gastrointestinal disorders 4.Smoking or alcohol consumption that may affect oral odor assessment 5.Use of medications known to cause halitosis 6.Cognitive impairment or inability to comply with study procedures 7.Allergies or contraindications to probiotic products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volatile sulfur compound levels Baseline, after first intervention period, after washout period, and after second intervention period Halitosis measured by volatile sulfur compound levels and organoleptic score; tongue coating and plaque assessed by clinical indices | — |
Secondary
| Measure | Time frame |
|---|---|
| Gingival bleeding index Bleeding on probing Gingival inflammation Baseline, after first intervention period, after washout period, and after second intervention period Gingival bleeding assessed using gingival bleeding index by recording bleeding after gentle probing with a periodontal probe. | — |
Countries
Thailand
Contacts
Public ContactPatcharaphol Samnieng
Naresuan University
Outcome results
None listed