Reflux Esophagitis Esomeprazole
Conditions
Interventions
The standard esomeprazole (Astrazeneca, National Drug Approval No. H20046380, 40mg per tablet) treatment is administered at a dose of 40mg once daily, 30 minutes before meals, for a course of 8 weeks,
Active Comparator Drug,Experimental Drug,Experimental Drug,Experimental Drug
control group,low-dose group,medium-dose group,high-dose group
Sponsors
Beijing Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Have good compliance with the prescribed treatment and follow-up procedures; (2) Agreed to participate in this study and signed the informed consent; (3) Meet the above-mentioned diagnostic criteria for RE; (4) Aged > 18 years.
Exclusion criteria
Exclusion criteria: (1) gastrointestinal bleeding, malignant tumor, long-segment Barrett's esophagus, esophageal stricture, esophageal varices, endoscopically confirmed esophageal stricture, or eosinophilic esophagitis; (2) a history of gastrointestinal surgery (apart from endoscopic resection); (3) an allergy to antacids or PPIs; (4) Malignant tumor history within the previous five years; (5) Patients with severe respiratory, central nervous, endocrine, or cardiovascular system diseases; (6) Having diseases of the liver or kidneys that are clinically important; (7) Women who are pregnant or nursing; (8) Those who have a history of mental illness; (9) Those who intend to be hospitalized or have surgery during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endoscopic remission rate at 8-week Endoscope | — |
Secondary
| Measure | Time frame |
|---|---|
| symptom scores before and after treatment Gastroesophageal Reflux Disease Questionnaire,quality of life before and after treatment GERD-Health Related Quality of Life (GERD-HRQL) scale | — |
Countries
China
Contacts
Public ContactYe Zhao
Beijing Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed