A Comparative Analysis of Fetal Middle Cerebral Blood Flow Using 3D Power Doppler Ultrasound as a Predictor of Adverse Perinatal Outcomes in Pregnancy Induced Hypertension and Normotensive Controls

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20260415005

Enrollment

228

Registered

2026-04-15

Start date

2026-04-04

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertensive disorders in pregnancy, including preeclampsia, and their effects on fetal cerebral circulation Pregnancy induced hypertension 3DPDU

Interventions

Singleton pregnant women with gestational age between 34 0 and 39 0/6 weeks who undergo ultrasonography and have hypertensive disorders during pregnancy or pre-existing hypertension. Participants will

Diagnostic,Diagnostic

Hypertensive Pregnancy Group,Normotensive Pregnancy Group

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Singleton pregnancy 2. Gestational age between 34 0/6 and 39 0/6 weeks (confirmed by first-trimester ultrasound or before 22 weeks of gestation) 3. Maternal age more than 18 years at the time of enrollment 4. Live fetus 5. Delivery at Bhumibol Adulyadej Hospital 6. Written informed consent obtained

Exclusion criteria

Exclusion criteria: 1. Pregnant women with the following underlying diseases: - Human immunodeficiency virus (HIV) infection - Systemic lupus erythematosus (SLE) - Autoimmune diseases - Liver disease - Heart disease - Renal disease 2. Confirmed fetal chromosomal or genetic abnormalities 3. Confirmed fetal structural anomalies

Design outcomes

Primary

Measure	Time frame
Fetal cerebral perfusion indices At the time of ultrasound examination between 34+0 and 39+6 weeks of gestation Measured by two-dimensional and three-dimensional power Doppler ultrasonography, including MCA-PI, UA-PI, CPR, vascularization index (VI), flow index (FI), and vascularization-flow index (VFI)	—

Secondary

Measure	Time frame
Adverse maternal outcomes At delivery and during the neonatal period until hospital discharge Assessed from delivery and neonatal records, including birth weight, 5-minute Apgar score, birth asphyxia, fetal growth restriction, NICU admission, RDS, BPD, IVH grade 3 , NEC, neonatal death,Adverse maternal outcomes From enrollment until delivery Assessed from medical records, including severe preeclampsia, preterm birth, postpartum hemorrhage, placental abruption, maternal anemia, gestational age at delivery, mode of delivery,Adverse neonatal outcomes At delivery and during the neonatal period until hospital discharge Assessed from delivery and neonatal records, including birth weight, 5-minute Apgar score, birth asphyxia, fetal growth restriction, NICU admission, RDS, BPD, IVH grade 3 , NEC, neonatal death	—

Measure

Time frame

Adverse maternal outcomes At delivery and during the neonatal period until hospital discharge Assessed from delivery and neonatal records, including birth weight, 5-minute Apgar score, birth asphyxia, fetal growth restriction, NICU admission, RDS, BPD, IVH grade 3 , NEC, neonatal death,Adverse maternal outcomes From enrollment until delivery Assessed from medical records, including severe preeclampsia, preterm birth, postpartum hemorrhage, placental abruption, maternal anemia, gestational age at delivery, mode of delivery,Adverse neonatal outcomes At delivery and during the neonatal period until hospital discharge Assessed from delivery and neonatal records, including birth weight, 5-minute Apgar score, birth asphyxia, fetal growth restriction, NICU admission, RDS, BPD, IVH grade 3 , NEC, neonatal death

—

Countries

Thailand

Contacts

Public ContactNetpreeya Nakngam

OBGYN, Bhumibol Adulyadej Hospital

Palapreawmed18@gmail.com025347758

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026