Patients age 18 to 80 years old who scheduled for elective middle ear surgery at King Chulalongkorn Memorial Hospital Postoperative nausea and vomiting, middle ear surgery
Conditions
Interventions
Palonosetron 1 mcg/kg IV after induction, an equivalent volume of normal saline 30 mins before end surgery ,Dexamethasone 4 mg IV + Palonosetron 0.5 mcg/kg IV after induction, an equivalent volume
Palonosetron alone (Group P),Dexamethasone + Palonosetron (Group DP),Dexamethasone + Normal saline (Group DO)
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 80 years old 2. Undergoing for elective middle ear surgery at King Chulalongkorn Memorial Hospital 3. Patients classified as American Society of Anesthesiologists (ASA) physical status I, II and III
Exclusion criteria
Exclusion criteria: 1. Patients who decline to participate in the study 2. Patients with a history of allergy or contraindication to dexamethasone, ondansetron, palonosetron, or any other drugs used in the study 3. Pregnant patients 4. Patients with chronic opioid use (opioid therapy >3 months) 5. Patients receiving antipsychotic medications 6. Patients who have received prophylactic or therapeutic antiemetic drugs within 24 hours prior to surgery 7. Patients who have received chemotherapy within 4 weeks before surgery 8. Patients who are not extubated after surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting (PONV) within 24 hours after surgery Within 24 hours after surgery Postoperative nausea and vomiting (PONV) score | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting (PONV) within 48 hours after surgery Within 48 hours after surgery Postoperative nausea and vomiting(PONV) score,Severity of PONV at postoperative time intervals Within 48 hours after surgery Postoperative nausea and vomiting(PONV) score,Total amount of rescue antiemetic medications administered within 48 hours postoperatively Within 48 hours after surgery Total amount of rescue antiemetic medications,Duration of stay in the post-anesthesia care unit (PACU) - Duration of stay in post-anesthesia care unit (PACU),Incidence of dizziness, headache, sore throat Within 48 hours after surgery VAS score,Patient satisfaction with PONV prophylaxis Within 48 hours after surgery Likert scale | — |
Countries
Thailand
Contacts
Public ContactKullaporn Mingvoramethakul
Chulalongkorn University
Outcome results
None listed