Post cardiopulmonary bypass hemostasis disorder Thrombocytopenia after cardiac surgery Coagulopathy after cardiac surgery Hypofibrinogenemia after cardiopulmonary bypass Cardiac surgery with cardiopulmonary bypass Cardiopulmonary bypass Cardiac surgery Hemostasis disorders Thrombocytopenia Coagulopathy Fibrinogen Blood coagulation Perioperative care Transfusion Risk factors
Conditions
Interventions
Adult patients undergoing cardiac surgery
Other
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 20 years or older undergoing surgery at Maharaj Nakorn Chiang Mai Hospital 2. Scheduled for elective cardiac surgery requiring cardiopulmonary bypass 3. Provided informed consent for study participation
Exclusion criteria
Exclusion criteria: 1. Patient refusal 2. Emergency cardiac surgery 3. Preexisting hemostasis disorder defined as platelet count less than 100000 cells per mm3 INR greater than 1.5 or fibrinogen less than 150 mg per dL 4. Severe hepatic dysfunction defined as AST or ALT greater than 3 times normal 5. Chronic kidney disease stage 4 or 5 or end stage renal disease 6. Hematologic disorders 7. Use of antiplatelet or anticoagulant therapy without adequate discontinuation except low dose aspirin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post CPB thrombocytopenia 5 minutes after separation from cardiopulmonary bypass Platelet count less than 100000 cells per cubic millimeter measured after cardiopulmonary bypass following protamine reversal | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypofibrinogenemia 5 minutes after separation from cardiopulmonary bypass Fibrinogen level less than 150 milligrams per deciliter,Coagulopathy 5 minutes after separation from cardiopulmonary bypass International normalized ratio greater than 1 point 5 measured after cardiopulmonary bypass | — |
Countries
Thailand
Contacts
Public ContactWariya Sukhuprakan
Faculty of Medicine, Chiang Mai University
Outcome results
None listed