Smoke Inhalation Injury, Thermal Burns, Acute Respiratory Failure Inhalation injury, bronchoscopy, nebulized heparin, N-acetylcysteine, driving pressure, static compliance
Conditions
Interventions
Patients received an initial therapeutic flexible fiberoptic bronchoscopy followed by scheduled therapeutic bronchoscopies performed daily for the first 3 days, then on alternate days. Concurrently, t
Scheduled Bronchoscopy with Nebulized Heparin and N acetylcysteine,Standard Airway Management
Sponsors
Viet Nam National Burn Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 65 years. 2. Sustained acute thermal burns. 3. Presented with bronchoscopically confirmed smoke inhalation injury within 24 hours of admission requiring invasive mechanical ventilation.
Exclusion criteria
Exclusion criteria: 1. Presence of a bleeding diathesis or concurrent therapeutic anticoagulation. 2. Severe chronic lung disease (GOLD 3-4 COPD). 3. Known allergy to heparin or N-acetylcysteine (NAC). 4. Pregnancy. 5. Expected survival of less than 72 hours as determined by a consensus of two senior intensivists.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day all cause mortality Day 28 Patient survival status,Severity of pulmonary impairment Day 7 Lung Injury Score | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of ventilator associated pneumonia Day 28 Modified CDC criteria,Respiratory mechanics Baseline and Day 7 Driving pressure and static compliance,Ventilator free days Day 28 Number of days without mechanical ventilation | — |
Countries
Vietnam
Contacts
Public ContactNhu Lam Nguyen
Viet Nam National Burn Hospital
Outcome results
None listed