Post-operative Pain of Endoscopic versus Mini-open Carpal Tunnel Release: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260405007

Enrollment

Registered

2026-04-05

Start date

2026-01-12

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients more than 18 years with clinically diagnosed Carpal Tunnel Syndrome Carpal Tunnel Syndrome, Fail conservative

Interventions

Endoscopic carpal tunnel release, using a single-portal endoscopic system, offers the theoretical advantages of reduced incisional trauma, earlier return to activities, and diminished pillar pain comp

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

Endoscopic carpal tunnel release,Mini-open carpal tunnel release

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) diagnosis of CTS at Police General Hospital 2) failure of conservative management for at least 3 months, including oral medications, wrist splinting, and/or corticosteroid injection 3) agreement to undergo surgical treatment.

Exclusion criteria

Exclusion criteria: 1) prior ipsilateral wrist or carpal bone fracture or dislocation 2) previous ipsilateral carpal tunnel surgery 3) significant comorbidities including cervical disc herniation with radiculopathy, cubital tunnel syndrome, wrist joint arthritis, thoracic outlet syndrome, Buergers disease, hypothyroidism, or diabetes mellitus 4) thenar muscle weakness detected on preoperative physical examination 5) unwillingness or discomfort with study participation 6) cognitive impairment affecting ability to respond to questionnaires 7) inability or unwillingness to complete a minimum of 3 months of postoperative follow-up.

Design outcomes

Primary

Measure	Time frame
Post-operative pain post-operative day 1 Visual analog score	—

Secondary

Measure	Time frame
Post-operative pain postoperative day 2 through week 12 Visual analog score,Symptom Severity score postoperative 1,2 and 3 months Boston Carpal Tunnel Questionnaire Symptom Severity Scale,Grip strength postoperative 1,2 and 3 months kilogram,Pinch strength postoperative 1,2 and 3 months Kilogram,Return to work time number of days from surgery until the patient self reported resumption of their usual occupational activities day,Patient satisfaction Postoperative 3 months 5 point Likert scale,Scar satisfaction Postoperative 3 months 5-point Likert scale,Post-operative complications Postoperative 3 months Categorical (Occurrence vs. Non occurrence),Re-operation rate Postoperative 3 months Categorical (Occurrence vs. Non occurrence)	—

Measure

Time frame

Post-operative pain postoperative day 2 through week 12 Visual analog score,Symptom Severity score postoperative 1,2 and 3 months Boston Carpal Tunnel Questionnaire Symptom Severity Scale,Grip strength postoperative 1,2 and 3 months kilogram,Pinch strength postoperative 1,2 and 3 months Kilogram,Return to work time number of days from surgery until the patient self reported resumption of their usual occupational activities day,Patient satisfaction Postoperative 3 months 5 point Likert scale,Scar satisfaction Postoperative 3 months 5-point Likert scale,Post-operative complications Postoperative 3 months Categorical (Occurrence vs. Non occurrence),Re-operation rate Postoperative 3 months Categorical (Occurrence vs. Non occurrence)

—

Countries

Thailand

Contacts

Public ContactKorntanat Thongvinij

Department of Orthopaedic Surgery, Police General Hospital

JFreserch@gmail.com02 207 6000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026