Pain associated with core needle biopsy in patients with suspected bone and soft tissue tumors (musculoskeletal tumors) Core needle biopsy
Conditions
Interventions
Local anesthesia will be administered using 2% lidocaine with adrenaline (9 mL) combined with tramadol 50 mg (1 mL). A waiting period of 5 minutes will be observed before performing the core needle bi
Experimental Drug,Active Comparator Drug
Tramadol + Lidocaine,Lidocaine alone
Sponsors
Maha Vajiralongkorn Foundation, Phramongkutklao Hospital
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1. Patients attending the outpatient department of the Orthopedic Division, Phramongkutklao Hospital 2.Patients diagnosed with a bone or soft tissue tumor of the extremities (upper or lower limbs) with an indication for core needle biopsy 3.Patients undergoing core needle biopsy for the first time 4.Age 20 years or older 5.Patients with tumors without pre-existing pain at the biopsy site
Exclusion criteria
Exclusion criteria: Exclusion Criteria 1.Patients with comorbidities that may affect pain perception (e.g., diabetes mellitus, menstrual-related conditions) 2.Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) 3.Known allergy to paracetamol, tramadol, or lidocaine 4.Patients with needle phobia 5.Patients with contraindications to core needle biopsy 6.Patients with impaired consciousness or inability to fully cooperate 7.Patients who decline participation or refuse to provide informed consent 8.Tumors located in highly sensitive areas with dense nerve distribution (e.g., hand, foot) 9.Patients who are unable to complete follow-up or are lost to follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity (Numeric Rating Scale, NRS) at 0, 1, 6, 12, 24, and 48 hours after core needle biopsy 0, 1, 6, 12, 24, and 48 hours Numeric Rating Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first use of oral analgesics after biopsy within 48 hours after end of the intervention hours,Total consumption of oral analgesics after biopsy within 48 hours after end of the intervention tab,Diagnostic concordance rate between biopsy results and final diagnosis (%) within one year after end of the intervention Diagnostic Concordance Rate (%) | — |
Countries
Thailand
Contacts
Public ContactSila Weeramatpakorn
Department of Orthopaedic Surgery, Phramongkutklao Hospital
Outcome results
None listed