Head and neck squamous cell carcinoma Pulmonary tuberculosis Active pulmonary tuberculosis Head and neck cancer Tuberculosis Pulmonary tuberculosis Prediction model Logistic regression Body mass index Hemoglobin Albumin Calibration Decision curve analysis
Conditions
Interventions
Participants with confirmed active pulmonary tuberculosis during pretreatment evaluation,Participants without confirmed active pulmonary tuberculosis during pretreatment evaluation
Diagnostic,Diagnostic
active pulmonary tuberculosis,Non active pulmonary tuberculosis
Sponsors
Chawalit Lakdee
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adults aged 18 years or older 2. Histopathologically confirmed head and neck squamous cell carcinoma 3. Underwent pretreatment evaluation prior to concurrent chemoradiotherapy at Buddhachinaraj Phitsanulok Hospital during Oct 2014 to Oct 202
Exclusion criteria
Exclusion criteria: 1. Prevalent tuberculosis treated before cancer diagnosis or before pretreatment evaluation 2. HIV infection 3. Strong immunosuppressive drugs at baseline such as systemic corticosteroids or chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Active pulmonary tuberculosi During pretreatment evaluation before concurrent chemoradiotherapy Confirmed diagnosis by positive microbiology or compatible chest imaging with anti tuberculosis treatment started | — |
Secondary
| Measure | Time frame |
|---|---|
| Model performance At model development using baseline data AUC ROC calibration and bootstrap internal validation with shrinkage decision curve analysis | — |
Countries
Thailand
Contacts
Public ContactChawalit Lakdee
Buddhachinaraj Phitsanulok Hospital
Outcome results
None listed