Healthy Thai adult aged 18 to 40 years with oily facial skin Oily skin, Seborrhea, botulinum toxin A, resorvoir-backed microneedle patch, microneedle patch
Conditions
Interventions
20 unit(1ml) of botulinum toxin A delivered via resorvoir- backed microneele patch at one side of narsal dorsum and cheek, applied for 15 minutes,1 ml of normal saline delivered via resorvoir- backed
Experimental Drug,Placebo Comparator No treatment
Botulinum toxin A delivered via resorvoir-backed microneedle patch,Normal saline delivered via resorvoir-backed microneedle patch
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Thai adult aged 18-40 years 2. Clinical oily facial skin with 15 or more of Six-item skin oiliness scale score 3. Elevated baseline ebum level at nasal dorsum and cheek morethan 106 microgram per square centimeters 4. Willing to refrain from using othe sebum reduction treatment during study period 5. Provided informed consent form
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women 2. Active local skin infections 3. Botulinum toxin A allergy or hypersensitivity reaction 4. Neuromuscular disease e.g. MG, LE, MS 5. Immunodeficiency 6. History of coagulopathy or anti-coagulant medication 7. History of keloid or hypertrophic scar 8. Current use of topical sebum reduction product or treatment in the past 1 month 9. Current use of Isotretinoin, spironolactone or oral contraceptive in the past 3 months 10. Current use of aminoglycosides, succinylcholine, cyclosporine, D-penicillamine, quinidine, aminoquinolones, magnesium sulfate, lincosamides 11. Botulinum toxin A injection, photodynamic therapy or laser treatment in the past 3 months 12. Unable to read or write in Thai
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sebum level At 1 month and 4 months after end of the intervention Sebumeter | — |
Secondary
| Measure | Time frame |
|---|---|
| Feature count of pore At 1 month and 4 months after end of the intervention VISIA 7th generation,Quality of life At 1 month and 4 months after end of the intervention Oily skin self-image questionnaire ,Patient satisfaction At 1 month and 4 months after end of the intervention Likert satisfaction scale,Adverse event At postintervention, 48 hours, 1 month and 4 months after end of the intervention Visual analogue scale | — |
Countries
Thailand
Contacts
Public ContactPantira Dheerachaikulpanich
Dhurakij Pundit University
Outcome results
None listed