Clinical characteristics and genetic studies for identifying monogenic diabetes among Thai individuals with young-onset diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20260401018

Enrollment

150

Registered

2026-04-01

Start date

2026-03-23

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Young-Onset Diabetes YOD, Young, Diabetes, Thai

Interventions

Age at diabetes onset less than 40 years with Thai nationality

Diagnostic

Young-Onset DM

Eligibility

Sex/Gender

All

Age

15 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age at diabetes onset < 40 years 2. Self-reported Thai ethnicity 3. Thai ancestry/Thai nationality 4. Provision of written informed consent for targeted MODY gene panel sequencing and polygenic risk score (PRS) testing

Exclusion criteria

Exclusion criteria: 1. Individuals with a previous confirmed diagnosis of monogenic diabetes or other established secondary forms of diabetes 2. Decline or withdrawal of consent for genetic or genomic testing 3. Positive anti-GAD (glutamic acid decarboxylase) autoantibodies, indicating autoimmune diabetes 4. Age more than 80 years at enrolment 5. Missing key clinical variables required for MODY Calculator estimation (Systolic BP, Fasting TG/HDL/LDL/ Fasting plasma C-peptide)

Design outcomes

Primary

Measure	Time frame
MODY cases At the beginning of study Molecular diagnostic rate,Factors to predict MODY cases At the beginning of study Factors analysis	—

Secondary

Measure	Time frame
Polygenic Risk Score for T1D/T2D N/A Results of Polygenic Risk Score	—

Countries

Thailand

Contacts

Public ContactYOTSAPON THEWJITCHAROEN

Vimut-Theptarin Hospital

kamijoa@hotmail.com0892097154

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026