Preoperative Stereotactic Radiosurgery/Radiotherapy followed by craniotomy with tumor resection in limited brain metastasis: A prospective single institution, pilot study in Chulabhorn Hospital

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260401014

Enrollment

Registered

2026-04-01

Start date

2025-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Limited Brain Metastasis requiring craniotomy with tumor removal Preoperative stereotactic radiosurgery, Radiosurgery, Brain metastasis, Radiotherapy, Neurosurgery

Interventions

Patient will recieve preoperative stereotactic radiosurgery before surgery equal or less than 7 days. Patients will be followed up with MRI brain every 3 months until 1 year after preoperative stereot

Experimental Radiation

Preoperative stereotactic radiosurgery

Eligibility

Sex/Gender

All

Age

20 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age equal or more than 20 years. 2. Patients with 1 to 4 brain metastases identified on MRI scan with at least one lesion amenable to surgical resection. 3. Maximum diameter of each lesion equal or less tham 4 cm. 4. ECOG Performance Status equal or less than 2. 5. Able to follow instructions and remain still for stereotactic radiosurgery. 6. Medically fit for surgery.

Exclusion criteria

Exclusion criteria: 1. Patients with germ cell tumors, small cell carcinoma, or hematologic malignancies. 2. Patients with primary brain cancer. 3. Prior treatment with whole-brain radiotherapy. 4. Evidence of leptomeningeal metastasis, either on MRI or by positive CSF cytology. 5. Patients requiring urgent surgical intervention, such as those with significant mass effect deemed by a neurosurgeon to require immediate surgery, hydrocephalus, compression of the fourth ventricle, or who are neurologically unstable. 6. Prior emergency decompressive surgery. 7. Pregnant or breastfeeding patients.

Design outcomes

Primary

Measure	Time frame
Leptomeningeal metastasis rate 12 months after intervention Descriptive analysis	—

Secondary

Measure	Time frame
Local recurrence rate 12 months after intervention Descriptive analysis,Distant brain failure rate 12 months after intervention Descriptive analysis,Radiation necrosis 12 months after intervention Descriptive analysis,Overall survival 12 months after intervention The Kaplan Meier method	—

Countries

Thailand

Contacts

Public ContactRuja Vichitvejpaisal

Chulabhorn Hospital

ruja.sri@cra.ac.th0909747321

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026