Weakness in the upper limb function in individuals with chronic stroke CHRONIC STROKE/ MOTOR TRAINING / BILATERAL TRAINING/TASK-SPECIFIC TRAINING/ UPPER LIMB TRAINING/ TRANSCRANIAL MAGNETIC STIMULATION/ THETA BURST STIMULATION/REACH-TO-GRASP/ CORTICOSPINAL EXCITABILITY
Conditions
Interventions
Thata-brust stimulation works on the lesion side of the brain and trains both hands in an individual with chronic stroke. ,Sham brain stimulation works on the lesion side of the brain but not the magn
Thata brust brain stimulation and bilateral training,Sham brain stimulation and bilateral training.
Sponsors
Faculty of Physical Therapy, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) First-time subcortical ischemic stroke or subcortical hemorrhagic stroke occurring more than 6 months ago. 2) Age between 40 and 80 years 3) Fugl-Meyer Assessment of Upper Extremity score between 30 and 57, indicating moderate impairment. 4) Adequate cognitive function, defined as a Mini-Mental State Examination Thai version 2022 score of more than 23 for individuals with an education level higher than Grade 12, more than 18 for those with primary school education or below, and more than 15 for uneducated participants. 5) Able to sit independently for at least 2 hours without assistance. 6) Able to perform a reach-and-grasp (RTG) task, such as reaching and opening a hand sufficiently to grasp a 4 cm object and wrist extension 10 degrees. 7) Normal or corrected hearing and vision, to ensure full participation in instructions and task performance.
Exclusion criteria
Exclusion criteria: 1) Contraindications for Transcranial Magnetic Stimulation (TMS), such as seizures, as confirmed by a TMS screening questionnaire. 2) Have lesion(s) in other brain area(s) such as occipital, brainstem, cerebellar, and if brain damage was bilateral or of non-vascular origin. 3) Pain issues in two or more upper extremity joints (e.g., shoulder, elbow, wrist), as assessed by the Fugl-Meyer of the upper extremity section. 4) Present with other neurological disorders 5) Concurrent or recent participation in other brain stimulation protocols, including TMS or tDCS 6) Unstable vital signs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corticospinal excitability at baseline, session 5, sesion 10 and follow-up 1 week after intervention Transcranial magnetic stimulation,Cortico reorganization at baseline, session 5, sesion 10 and follow-up 1 week after intervention Transcranial magnetic stimulation,kinematic reach-to-grasp movement at baseline, session 5, sesion 10 and follow-up 1 week after intervention MotionMonitor system | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life at baseline, session 5, sesion 10 and follow-up 1 week after intervention Stroke impact scale (SIS) | — |
Countries
Thailand
Contacts
Public ContactPhapvijid Seangsanor
Faculty of Physical Therapy, Mahidol University
Outcome results
None listed