Septic shock requiring a norepinephrin Septic shock Methylene blue Catecholamine-sparing agent
Conditions
Interventions
Methylene blue 100 mg was administered intravenously as a continuous infusion over 6 hours once daily, continued until vasopressor discontinuation or for a maximum of 72 hours.,Methylene blue was admi
Experimental Drug,Experimental Drug
6-Hour continuous infusion,Bolus injection with continuous infusion
Sponsors
Navamindradhiraj University Research Fund
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age greater than or equal to 18 years 2.Diagnosis of septic shock according to Sepsis 3 criteria 3.Evidence of fluid unresponsiveness despite adequate fluid resuscitation assessed by at least one of the following procedures (CVP, PAOP, PLRT, IVC, PPV) 4.Receiving norepinephrine infusion at a dose greater than or equal to 0 point 2 mcg per kg per min with either mean arterial pressure MAP less than 65 mmHg or serum lactate greater than 2 mmol per L after at least 1 hour of norepinephrine administration prior to study enrollment
Exclusion criteria
Exclusion criteria: 1.Severe glucose-6-phosphate dehydrogenase (G6PD) deficiency, confirmed by G6PD screening test. 2.History of severe allergy to methylene blue. 3.Pregnancy, confirmed by urine pregnancy test in women of childbearing age or in those with amenorrhea. 4.Patients who refuse treatment or are in the terminal stage of illness (do-not-resuscitate [DNR] status or terminally ill).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vasopressor duration Until vasopressor therapy is discontinued Number of hours / Determined from hospital records | — |
Secondary
| Measure | Time frame |
|---|---|
| Vasopressor-free days At 28 days post-intervention Number of days / Determined from hospital records,28-day hospital mortality At 28 days post-intervention Number of days / Determined from hospital records,Length of hospital stay Upon discharge post-intervention Number of days / Determined from hospital records,Length of ICU stray Upon discharge from ICU post-intervention Number of days / Determined from hospital records | — |
Countries
Thailand
Contacts
Public ContactSupattra Chiewroongroj
Faculty of Medicine Vajira Hospital, Navamindradhiraj University
Outcome results
None listed