There are few retrospective data and one prospective showed no different in coronary artery aneurysm event outcomes between patients receiving low-, medium- and high-dose aspirin. The updated guideline state medium- and high-dose are acceptable as initial treatment. However, the prospective randomized control trial is still lacking. Kawasaki disease, aspirin
Conditions
Interventions
Initial low dose aspirin with 3-5 mg/kg/day, but main treatment with IVIg and IV methylprednisolone per guideline,Initial medium dose aspirin with 30-50 mg/kg/day, but main treatment with IVIg and IV
Active Comparator Drug,Active Comparator Drug,Active Comparator Drug
Low-dose aspirin,Medium-dose aspirin,High-dose aspirin
Sponsors
No Study Secondary Sponsor
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients age 1 month to 18 years who diagnosed with Kawasaki disease based on AHA criteria at Siriraj hospital, Chonburi hospital, Sawanpracharak hospital, Prapokklao Chanthaburi hospital, Nakhon Pathom hospital, Khon Kaen hospital and Srinakharinwirot University hospital
Exclusion criteria
Exclusion criteria: 1. Prior Aspirin treatment from other diseases or prior aspiring prescribed in newly diagnose Kawasaki disease and received aspirin for more than 24 hours 2. Severe comorbidities or contraindications to receiving Aspirin such as liver failure, chronic kidney disease, acute renal failure, varicella or influenza co-infection, previously documented severe adverse drug reaction to NSAIDS, active upper gastrointestinal bleeding or serious bleedings 3. Afebrile prior to treat KD by IVIg and Aspirin 4. Known to have underlying of vasculitis or autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary arteries aneurysm 6-8 weeks Echocardiogram | — |
Secondary
| Measure | Time frame |
|---|---|
| Coronary arteries aneurysm 1 year Echocardiogram ,Fever days Days post-IVIG days | — |
Countries
Thailand
Contacts
Public ContactChodchanok Vijarnsorn
Faculty of Medicine Siriraj Hospital
Outcome results
None listed