Diabetic kidney disease Chronic kidney disease Diabetic kidney disease Chronic kidney disease weight control intermittent fasting albuminuria overweight
Conditions
Interventions
Time-restricted eating (8 a.m. to 4 p.m.) + Commercial renal-specific low-protein supplementation 5 scoops per day with Dietary guidance from dietitian in total of 25 to 30 kcal per kg per day and 0.8
Experimental Dietary Supplement,No Intervention No treatment
Intermittent fasting + renal-specific low-protein supplementation,control
Sponsors
Phramongkutklao Hospital
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 20 years 2. Diabetes 3. CKD stage 3b-4 4. BMI equal or more than 23 kg/m2 5. UACR equal or more than 300 mg/gCr 6. HbA1C <8.5% within 3 months 7. Stable dose of ACEI/ARB, SGLT2i, and nsMRA within 3 months 8. No use of GLP1-RA within 3 months
Exclusion criteria
Exclusion criteria: 1. Active infection 2. Advanced malignancy 3. Advanced liver disease 4. Use of sulfonylurea, short or intermediated-acting insulins 5. History of serious hypoglycemic symptoms 6. Low muscle mass: ASMI <7 in male and <5.7 in female
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine albumin-to-creatinine ratio at 12 weeks after start of the intervention Change in urine albumin-to-creatinine ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| Estimated Glomerular Filtration Rate at 12 weeks after start of the intervention change in Estimated Glomerular Filtration Rate,body weight at 12 weeks after start of the intervention change in body weight,body composition at 12 weeks after start of the intervention body composition by Bioelectrical impedance analysis | — |
Countries
Thailand
Contacts
Public ContactPatsakorn Saraggananda
Phramongkutklao hospital
Outcome results
None listed