Comparison of treatment efficacy and side effect rate between using 0.9%sodium chloride versus 1.8% sodium chloride nasal irrigation in patient with Idiopathic rhinitis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260327007

Enrollment

Registered

2026-03-27

Start date

2026-03-31

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic nasal symptoms and nasal congestion in patients with Idiopathic Rhinitis (Chronic Non-Allergic Rhinitis) Nonallergic Rhinitis, Idiopathic Rhinitis, Nasal Irrigation, Hypertonic Saline, Isotonic Saline, Nasal Congestion, Treatment Outcome, Randomized Controlled Trial

Interventions

Participants will perform nasal irrigation once daily for a total duration of 28 days. Each session involves using a 20 ml syringe to irrigate the nasal cavities with a total volume of 100 ml of 1.8 p

Active Comparator Other,Active Comparator Other

1.8 percent Sodium Chloride nasal irrigation solution,0.9 percent Sodium Chloride nasal irrigation solution

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Patients diagnosed with idiopathic rhinitis 2.Presence of persistent nasal symptoms including nasal congestion, runny nose, sneezing, or itching for more than 4 weeks 3.Willingness to perform daily nasal irrigation for 4 weeks as specified in the study protocol 4.No clinical evidence of nasal polyps or chronic rhinosinusitis 5.Ability to understand study procedures and provide written informed consent

Exclusion criteria

Exclusion criteria: 1.History of sinonasal surgery within the past 3 months 2.Current diagnosis of acute upper respiratory tract infection or acute sinusitis 3.Known allergy or hypersensitivity to any components of the study medications or saline solutions 4.Presence of anatomical nasal abnormalities such as significant nasal septal deviation that prevents effective irrigation 5.Current pregnancy or breastfeeding 6.Presence of severe underlying systemic diseases that might affect the study outcomes or patient safety

Design outcomes

Primary

Measure	Time frame
Visual Analog Scale for Global Nasal Symptom Score Time point (English): Baseline (Day 0), Day 14, and Day 28 after the start of the intervention Visual Analog Scale for Global Nasal Symptom Score	—

Secondary

Measure	Time frame
Visual Analog Scale for Nasal Irritation Score Time point (English): Baseline (Day 0), Day 14, and Day 28 after the start of the intervention Visual Analog Scale for Nasal Irritation Score	—

Countries

Thailand

Contacts

Public ContactPak Sriplienchan

Bhumibol Adulyadej Hospital, Directorate of Medical Services, Royal Thai Air Force

paksriplien45676@gmail.com0875887252

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026