Effect of personalized micronutrient supplementation among severe acute kidney injury patients undergoing renal replacement therapy : a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260324001

Enrollment

Registered

2026-03-24

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe acute kidney injury (KDIGO stage 3) in critically ill patients undergoing renal replacement therapy (CRRT or SLED) Critical illness acute kidney injury Renal replacement therapy Micronutrient supplementation SOFA score

Interventions

Participants in the intervention group will receive personalized micronutrient supplementation based on plasma levels of vitamin C, zinc, and selenium. Supplementation will be provided when deficiency

Experimental Dietary Supplement,No Intervention No treatment

micronutrient supplementation ,Standard of care

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1.Age more than 18 years 2.ICU patients with severe acute kidney injury KDIGO stage 3 3.Receiving renal replacement therapy CRRT or SLED 4. Informed consent obtained from patient or legal representative

Exclusion criteria

Exclusion criteria: 1.Use of oral nutritional supplements 2. ICU stay more than 7 days before enrollment 3. Receiving parenteral nutrition 4. History of kidney transplantation 5.Pregnancy or breastfeeding 6.Known allergy to study supplements 7.Acute liver failure or fulminant hepatitis

Design outcomes

Primary

Measure	Time frame
Change in Sequential Organ Failure Assessment-2 (SOFA-2) score 28 day Sequential Organ Failure Assessment-2 (SOFA-2) score calculated using clinical and laboratory parameters.	—

Secondary

Measure	Time frame
Duration of renal replacement therapy 28 days Number of days receiving renal replacement therapy recorded from medical records.,Length of ICU stay 28 days Number of days receiving renal replacement therapy recorded from medical records,Duration of mechanical ventilation 28 days Number of days receiving mechanical ventilation from initiation to discontinuation, obtained from medical records.,C-reactive protein (CRP) level 28 days Serum CRP level measured using standard laboratory assay from blood samples.,Interleukin-6 (IL-6) level 28 days Serum Interleukin-6 (IL-6) level measured using standard laboratory assay from blood samples.,Total antioxidant capacity 28 days Total antioxidant capacity measured using standard laboratory assay from blood samples.	—

Measure

Time frame

Duration of renal replacement therapy 28 days Number of days receiving renal replacement therapy recorded from medical records.,Length of ICU stay 28 days Number of days receiving renal replacement therapy recorded from medical records,Duration of mechanical ventilation 28 days Number of days receiving mechanical ventilation from initiation to discontinuation, obtained from medical records.,C-reactive protein (CRP) level 28 days Serum CRP level measured using standard laboratory assay from blood samples.,Interleukin-6 (IL-6) level 28 days Serum Interleukin-6 (IL-6) level measured using standard laboratory assay from blood samples.,Total antioxidant capacity 28 days Total antioxidant capacity measured using standard laboratory assay from blood samples.

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Countries

Thailand

Contacts

Public ContactBhurapol Prommongkol

Nephrology department King Chulalongkorn Memorial Hospital

bhpr.med@gmail.com0953545144

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026