Unresectable Head and Neck Squamous Cell Carcinoma Residual Disease Head and Neck Neoplasms Carcinoma, Squamous Cell Chemoradiotherapy Residual Neoplasm Logistic Models Treatment Outcome
Conditions
Interventions
Patients with unresectable head and neck squamous cell carcinoma who had residual disease at 8 to 12 weeks after completion of definitive concurrent chemoradiotherapy, as assessed by CT or MRI accordi
Other,Other
Residual disease,Complete response
Sponsors
Chawalit Lakdee
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 Patients aged 18 years or older. 2 Histologically confirmed head and neck squamous cell carcinoma. 3 Unresectable disease. 4 Treated with definitive concurrent chemoradiotherapy with cisplatin-based chemotherapy. 5 Pretreatment staging performed using CT or MR
Exclusion criteria
Exclusion criteria: 1 Previous radiotherapy. 2 Chemotherapy prior to concurrent chemoradiotherapy. 3 Distant metastasis at initial staging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Residual disease 8 to 12 weeks after completion of concurrent chemoradiothera Treatment response assessed by CT or MRI | — |
Secondary
| Measure | Time frame |
|---|---|
| Model performance At model development using baseline data AUC ROC calibration and bootstrap internal validation with shrinkage decision curve analysis | — |
Countries
Thailand
Contacts
Public ContactChawalit Lakdee
Buddhachinaraj Phitsanulok Hospital
Outcome results
None listed