Etomidate dose on older adult hemodynamics Etomidate, low dose, induction, intubation, emergency intubation, older adult, elderly, hemodynamic, blood pressure
Conditions
Interventions
Etomidate intravenous 0.15 mg/kg
,Etomidate intravenous 0.3 mg/kg
Active Comparator Drug,Active Comparator Drug
Reduced dose etomidate,Standard dose etomidate
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged 65 years or older who require emergency intubation while admitted to the ED 2. Induction before intubation with etomidate (based on treating physician's judgement) 3. Initial SBP 100 mmHg or higher
Exclusion criteria
Exclusion criteria: 1. Allergic to etomidate 2. Cardiac arrest before intubation 3. Transfer to another hospital 4.Trauma 5. History of corticosteroid use 6. Refusal/Decline to participate in the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post-intubation hypotension within 60 minutes within immediately after induction and at 5-minute intervals thereafter, for up to 60 minutes Postintubation hypotension criteria (lower than 90 mmHg or 20 percent lower than BP before intubation) | — |
Secondary
| Measure | Time frame |
|---|---|
| Initiation/increase dose of vasoactive agent(s) within 24 hours Starting or require higher dose of vasoactive agent(s) within 24 hours of intubation,Initiation of hydrocortisone use within 24 hours Requirement of hydrocortisone infusion within 24 hours of intubation,Cortisol profile at 0,12, and 24 hours after induction with etomidate Serum cortisol level,In hospital mortality within 30 days mortality rate,Rescue dose During emergency intubation Number of patients | — |
Countries
Thailand
Contacts
Public ContactADISAK NITHIMATHACHOKE
Faculty of Medicine Vajira Hospital Navamindradhiraj University
Outcome results
None listed