Multidomain Training Program for Physio-Cognitive Decline in Older Adults in Bangkok

Efficacy of a Multidomain Training Program (MDT-BKK) on Physio-Cognitive Decline Syndrome among Community-Dwelling Older Adults in Bangkok: A Pilot Cluster Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260321001

Enrollment

240

Registered

2026-03-21

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physio Cognitive Decline Syndrome Sarcopenia Cognitive Impairment Frailty Aged Cognition Disorders Muscle Strength Resistance Training Hand Strength Falls Quality of Life Cluster Randomized Trial

Interventions

Multidomain Training Program consisting of progressive resistance training dual task cognitive training and targeted protein nutrition delivered over 24 weeks Participants attend structured exercise s

Experimental Behavioral,No Intervention No treatment

MDT-BKK Multidomain Training Program,Usual Community Care

Eligibility

Sex/Gender

All

Age

65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Community dwelling adults aged 65 years and older residing in Bangkok Thailand 2.Screened as having Physio Cognitive Decline Syndrome defined by coexisting mild cognitive impairment and physical performance decline 3.Able to ambulate with or without assistive devices 4.Able to participate in exercise training 5.Provided written informed consent

Exclusion criteria

Exclusion criteria: 1.Diagnosis of dementia or major neurocognitive disorder 2.Severe cardiovascular pulmonary or musculoskeletal conditions limiting exercise participation 3.Unstable medical conditions 4.Severe psychiatric illness 5.Participation in other interventional studies

Design outcomes

Primary

Measure	Time frame
Handgrip Strength Change from baseline to week 24 Measured in kilograms using calibrated hand dynamometer,Montreal Cognitive Assessment (MoCA) total score Change from baseline to week 24 Measured using MoCA total score	—

Secondary

Measure	Time frame
Gait Speed Change from baseline to week 24 Measured using 4 meter walk test meters per second,Short Physical Performance Battery Score Change from baseline to week 24 Measured using SPPB total score,Body Composition Change from baseline to week 24 Measured using bioelectrical impedance analysis,Health Related Quality of Life Change from baseline to week 24 Measured using EQ 5D 5L Thai version index score,Incidence of Falls Week 24 Number of fall events recorded during 24 week follow up	—

Measure

Time frame

Gait Speed Change from baseline to week 24 Measured using 4 meter walk test meters per second,Short Physical Performance Battery Score Change from baseline to week 24 Measured using SPPB total score,Body Composition Change from baseline to week 24 Measured using bioelectrical impedance analysis,Health Related Quality of Life Change from baseline to week 24 Measured using EQ 5D 5L Thai version index score,Incidence of Falls Week 24 Number of fall events recorded during 24 week follow up

—

Countries

Thailand

Contacts

Public ContactNUENGRUETHAI SURATTANAPORNCHAI

Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University

Nuengruethai.phc48@gmail.com024212149

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026