Intestinal epithelial injury Transfusion associated necrotizing enterocolitis (TANEC) Transfusion associated circulatory overload (TACO) Prematurity Anemia Transfusion associated necrotizing enterocolitis (TANEC) Transfusion associated circulatory overload (TACO) Intestinal fatty acid-binding protein
Conditions
Interventions
Enteral feeding was stopped immediately after randomization and withheld for a total of 12 hours (4 hours before transfusion, during transfusion, and 4 hours after transfusion). For infants receiving
Experimental Procedure/Surgery,No Intervention Procedure/Surgery
Stopping enteral feeding during pRBC transfusion,Continuing feeding during pRBC transfusion
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Neonates born at 34-week gestation or less requiring packed RBC transfusion prior to a postmenstrual age (PMA) of 44 weeks
Exclusion criteria
Exclusion criteria: 1. Genetic syndrome 2. Congenital anomalies 3. Prior pRBC transfusion 4. NEC stage II or more 5. spontaneous intestinal perforation (SIP)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recruitment rate 12 months persons per month,Protocol adherence 12 hours percentage,Retention 48 hours after transfusion percentage,Hypoglycemia 4 hours during transfusion Percentage,Hyperglycemia 4 hours during transfusion percentage | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal fatty acid-binding protein pre- and post-transfusion Enzyme-linked immunosorbent assay,Transfusion-associated necrotizing enterocolitis 48 hours after transfusion clinical determination,Transfusion-associated circulatory overload 24 hours after transfusion clinical determination | — |
Countries
Thailand
Contacts
Public ContactSatit Manopunya
Chiang Mai University
Outcome results
None listed