Pediatric patients undergoing open heart surgery with cardiopulmonary bypass Dexmedetomidine Cardiopulmonary bypass Pediatric cardiac surgery Cerebral oxygenation S-100B Neuroprotection
Conditions
Interventions
Dexmedetomidine 0.5 microgram per kg diluted in 5 mL of 0.9 percent sodium chloride was added to the cardiopulmonary bypass priming solution. This was followed by a continuous infusion of dexmedetomid
Experimental Drug,Placebo Comparator No treatment
Dexmedetomidine,Sodium Chloride 0.9%
Sponsors
Defitra Nanda Sasmita
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Pediatric patients scheduled to undergo open heart surgery aged 0 to 18 years. 2. Patients diagnosed with congenital heart disease requiring elective open heart surgery using cardiopulmonary bypass.
Exclusion criteria
Exclusion criteria: 1. Patients whose surgical plan changes from elective surgery to emergency surgery. 2. Patients with impaired liver function indicated by serum glutamic oxaloacetic transaminase or serum glutamic pyruvic transaminase levels more than 1.5 times the upper normal limit. 3. Patients with active infection before surgery. 4. Patients with impaired renal function indicated by serum creatinine levels above 2 mg per dL. 5. Patients with coagulation disorders indicated by international normalized ratio above 1.5. 6. Patients diagnosed with pre existing brain injury or neurological abnormalities before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum S-100B Before cardiopulmonary bypass and 6 to 12 hours after surgery Serum S 100B measured from venous blood using enzyme linked immunosorbent assay,cerebral oxygenation T0 after anesthesia induction before CPB, T1 CPB initiation, T2 aortic cross clamp, T3 60 minutes after CPB start, T4 5 minutes after CPB end, T5 30 minutes after CPB, T6 60 minutes after CPB Absolute regional cerebral oxygen saturation using near infrared spectroscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of mechanical ventilation since admission to cardiac intensive care unit until extubation number of days, cardiac intensive care unit length of stay since admission to cardiac intensive care unit until discharged number of days,7 day mortality 7 days after surgery Patient clinical status. Discharged to ward, Still on ventilator or Death | — |
Countries
Indonesia
Contacts
Public ContactDefitra Sasmita
Faculty of Medicine, Universitas Indonesia
Outcome results
None listed