Comparative Evaluation of Five Desensitizing Agents for In-Office Relief of Dentin Hypersensitivity: A 4-Week Randomized Examiner-Blinded Trial

Comparative Evaluation of Five Desensitizing Agents (Potassium Nitrate, Arginine, NovaMin, Nano-Hydroxyapatite, and CPP-ACP) for In-Office Relief of Dentin Hypersensitivity: A 4-Week Randomized Examiner-Blinded Clinical Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260317003

Enrollment

100

Registered

2026-03-17

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition(s) or Problem(s) Studied: Dentin hypersensitivity

Interventions

INTERVENTION DESCRIPTION: GROUP 1 (PN) WASH-OUT AND AGENT: Participants will use Sensodyne Pronamel (5% potassium nitrate with 1450 ppm fluoride as sodium fluoride) during the 4-week washout to standa

Colgate-Palmolive). APPLICATION PROTOCOL: A single standardized in-office application will be performed. A pea-sized amount (approximately 0.3 g) of the agent will be burnished onto the hypersensitiv

Active Comparator Drug,Active Comparator Drug,Active Comparator Drug,Active Comparator Drug,Active Comparator Drug

Potassium Nitrate,Arginine,NovaMin,Nano-Hydroxyapatite, CPP-ACP

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1.Healthy patients at least two hypersensitive teeth (incisors, canines, or premolars) anterior to molars with cervical abrasion or gingival recession. 2. Less than 1 mm dentin loss not requiring restorative intervention. 3.Baseline tactile VAS greater than or equal to 4 on 100 mm scale. 4.Baseline Schiff Cold Air Sensitivity Score of 2 or 3. 5.Written informed consent provided by participant.

Exclusion criteria

Exclusion criteria: 1.Periodontal disease or periodontal treatment within 6 months 2.No Systemic disease, pregnancy, or lactation 3.Use of desensitizing toothpaste within 3 months 4.Use of antibiotics or analgesics within 6 months 5.Teeth with pulpitis, caries, cracked enamel, or extensive restorations 6.Known allergy to any study material, including milk protein (relevant to CPP-ACP) 7.Participation in another clinical trial within 30 days

Design outcomes

Primary

Measure	Time frame
Change in tactile sensitivity 4 weeks post-application 100-mm Visual Analog Scale (VAS)	—

Secondary

Measure	Time frame
Change in evaporative sensitivity 4 weeks post-application Schiff Cold Air Sensitivity Scale (0-3),Sensitivity change at 2 weeks 2 weeks post-application VAS and Schiff Scale,Responder rate 4 weeks post-application Proportion of patients achieving Greater Than or Equal To 50% VAS reduction from baseline.	—

Countries

Iraq

Contacts

Public ContactAhmed Mustafa

Department of operative dentistry

Sleibi1975@uomustansiriyah.edu.iq7901745920

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026