Fluid Balance-Guided versus Targeted Net Ultrafiltration Strategy in Critically Ill Patients Receiving Continuous Renal Replacement Therapy: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260316004

Enrollment

Registered

2026-03-16

Start date

2026-02-16

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically ill patients with Acute Kidney Injury (AKI) requiring Continuous Renal Replacement Therapy (CRRT) AKI Fluid overload Critically ill patients CRRT

Interventions

1.If Hypervolemia: Set net ultrafiltration (NUF) rate 1.5-1.75 mL/kg/h 2.If Euvolemia: Set NUF rate 1.0-1.5 mL/kg/h 3.Start NUF at 0.5 mL/kg/h and titrate up to target,1.If Hypervolemia: Target daily

Experimental Other,Experimental Other

Targeted Net Ultrafiltration (Target-NUF) Strategy,Fluid Balance-Guided Net Ultrafiltration (Balance-NUF) Strategy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age 18 years old or older 2.Diagnosed with Acute Kidney Injury (AKI) KDIGO stage 2-3 3.Receiving CRRT within 24 hours of meeting indications (refractory hyperkalemia, severe metabolic acidosis, diuretic resistance fluid overload, uremic complications) 4.Informed consent provided

Exclusion criteria

Exclusion criteria: 1.Palliative care / DNR 2.Post-cardiac surgery 3.Burn injury 4.Severe dysnatremia (>155 or <120 mmol/L) 5.Active hemorrhage requiring blood transfusion 6.Moribund state (expected death within 24 hours) 7.Pregnancy 8.End-Stage Renal Disease (ESRD) on maintenance dialysis

Design outcomes

Primary

Measure	Time frame
Cumulative Fluid Balance at 48 hours First 48 hours of CRRT The cumulative difference between total fluid input and total fluid output from CRRT initiation to 48 hours	—

Secondary

Measure	Time frame
28-day All-cause Mortality 28 days 28-day All-cause Mortality,Ventilator-free days 28 days Ventilator-free days,Vasopressor-free days 28 days Vasopressor-free days,Renal Recovery 28 days Renal Recovery,Hemodynamic instability related to RRT During CRRT treatment Hemodynamic instability related to RRT	—

Countries

Thailand

Contacts

Public ContactKompol Wongmaneechuchot

Bhumibol Adulyadej Hospital

kompol_landz@hotmail.com025347255

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026