Patients with acute respiratory failure presenting to an emergency department respiratory insufficiency emergency department noninvasive ventilation lung compliance respiratory mechanics
Conditions
Interventions
Adult patients with acute respiratory failure presenting to the emergency department and treating clinician decide that they will need high flow nasal cannula,Adult patients with acute respiratory fa
Basic Science,Basic Science
high flow nasal cannula,non invasive ventilation
Sponsors
Investigator
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients (age >=18 years old) presenting to the emergency department 2. Acute respiratory failure , as defined by presence of hypoxemia (with oxygen saturation measured by pulse oximetry (SpO2) less than 90% on room air) and either 1) Presence of respiratory effort such as the use of accessory muscle, paradoxical breathing or thoracoabdominal asynchrony, and 2) Tachypnea (respiratory rate of >25 breaths per min) 3. Treating clinician decide that the patient will need non-invasive respiratory support either 1) high-flow nasal cannula or 2) non-invasive ventilation (NIV)
Exclusion criteria
Exclusion criteria: 1. Patients who require immediate non-invasive respiratory support or intubation, preventing the informed consent process 2. Patients are ineligible for high-flow nasal cannula (HFNC) non-invasive ventilation (NIV) due to safety concerns 3. Patients with tracheostomy 4. Contraindication to Electrical impedance tomography (EIT) placement: pacemaker/defibrillator implementation, burns at the area of placement 5. Anticipate need for intubation within 60 minutes of screening 6. Do not intubate (DNI) or palliative intent only 7. Pregnancy 8. inability to obtain consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of parameters from Electrical impedance Tomography (EIT), Pleth variability index(PVI) from baseline to 30 minutes 30 min parameters from Electrical impedance Tomography (EIT), Pleth variability index(PVI) | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of parameters from Electrical impedance Tomography (EIT), Pleth variability index(PVI) from baseline to 1 hour 1 hour parameters from Electrical impedance Tomography (EIT), Pleth variability index(PVI),Change of parameters from Electrical impedance Tomography (EIT), Pleth variability index(PVI) from 30 min to 1 hour 1 hour parameters fromElectrical impedance Tomography (EIT), Pleth variability index(PVI),Different in changes of parameters from Electrical impedance Tomography, Pleth variability index comparing between the group of patients on high flow nasal cannula (HFNC) or Non invasive ventilation 30 min and 1 hour parameters from Electrical impedance Tomography (EIT), Pleth variability index(PVI),Intubation 7 days number of patients who underwent intubation,death 7 days number of patients who died,Duration of using non invasive ventilation 7 days duration,Emergency department length of stay 7 days Emergency department length of stay (hours) ,intensive care unit length of stay 28 days intensive care unit length of stay (days),hospital length of stay 28 days hospital length of stay (days),Hospital and ventilator free day up to day 28 28 days Hospital and ventilator free day up to day 28 (days) | — |
Countries
Thailand
Contacts
Public ContactJutamas Saoraya
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed