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RSV Breakthrough Infections in Hospitalized Children: Clinical and Genotypic Characterization Following Immunoprophylaxis with Monoclonal Antibodies or Maternal Vaccination

RSV Breakthrough Infections in Hospitalized Children: Clinical and Genotypic Characterization Following Immunoprophylaxis with Monoclonal Antibodies or Maternal Vaccination

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20260311009
Enrollment
122
Registered
2026-03-11
Start date
2026-02-22
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Population: Children below or equal to 2 years old diagnosed with RSV and admitted to King Chulalongkorn Memorial Hospital. RSV, children, mutation

Interventions

Children who received Palivizumab, Nirsevimab, Clesrovimab, or whose mothers were vaccinated with RSVpreF during pregnancy.,Children who received no immunoprophylaxis or are beyond the protection peri
Health Services Research,Health Services Research
Immunized children.,Nonimmunized children.

Sponsors

The Thai Redcross Society
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 2 Years

Inclusion criteria

Inclusion criteria: 1 Children must be no more than 2 years old. 2 Must be diagnosed with a respiratory tract infection with laboratory-confirmed RSV via rapid antigen test or PCR. 3 The patient must be admitted for inpatient treatment at the pediatric ward of King Chulalongkorn Memorial Hospital. 4 Guardians or legal representatives must provide written informed consent for data collection and, if applicable, the collection of additional specimens for genetic testing.

Exclusion criteria

Exclusion criteria: 1 Patients who have medical contraindications for respiratory specimen collection. This includes: 1.1 Prior surgery of the sinuses or skull base. 1.2 History of facial or skull base fractures. 1.3 Encephalocele (protrusion of the brain through a skull defect).

Design outcomes

Primary

MeasureTime frame
Clinical characteristics one time at medically attended visit Interview and review medical records

Secondary

MeasureTime frame
Genotypic analysis one time at medically attended visit Next generation sequencing

Countries

Thailand

Contacts

Public ContactNapaporn Chantasrisawad

King Chulalongkorn Memorial Hospital

Napaporn.cha@chula.ac.th0867225606

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026